Interventions to Improve Neonatal Health and Later Survival: An Overview of Systematic Reviews

Show simple item record Lassi, ZS en Middleton, PF en Crowther, Caroline en Bhutta, ZA en 2015-11-15T22:11:18Z en 2015-05-22 en 2015-08 en
dc.identifier.citation EBioMedicine, 2015, 2 (8), pp. 985 - 1000 en
dc.identifier.uri en
dc.description.abstract BACKGROUND: Evidence-based interventions and strategies are needed to improve child survival in countries with a high burden of neonatal and child mortality. An overview of systematic reviews can focus implementation on the most effective ways to increase child survival. METHODS: In this overview we included published Cochrane and other systematic reviews of experimental and observational studies on antenatal, childbirth, postnatal and child health interventions aiming to prevent perinatal/neonatal and child mortality using the WHO list of essential interventions. We assessed the methodological quality of the reviews using the AMSTAR criteria and assessed the quality of the outcomes using the GRADE approach. Based on the findings from GRADE criteria, interventions were summarized as effective, promising or ineffective. FINDINGS: The overview identified 148 Cochrane and other systematic reviews on 61 reproductive, maternal, newborn and child health interventions. Of these, only 57 reviews reported mortality outcomes. Using the GRADE approach, antenatal corticosteroids for preventing neonatal respiratory distress syndrome in preterm infants; early initiation of breastfeeding; hygienic cord care; kangaroo care for preterm infants; provision and promotion of use of insecticide treated bed nets (ITNs) for children; and vitamin A supplementation for infants from six months of age, were identified as clearly effective interventions for reducing neonatal, infant or child mortality. Antenatal care, tetanus immunization in pregnancy, prophylactic antimalarials during pregnancy, induction of labour for prolonged pregnancy, case management of neonatal sepsis, meningitis and pneumonia, prophylactic and therapeutic use of surfactant, continuous positive airway pressure for neonatal resuscitation, case management of childhood malaria and pneumonia, vitamin A as part of treatment for measles associated pneumonia for children above 6 months, and home visits across the continuum of care, were identified as promising interventions for reducing neonatal, infant, child or perinatal mortality. INTERPRETATION: Comprehensive adoption of the above six effective and 11 promising interventions can improve neonatal and child survival around the world. Choice of intervention and degree of implementation currently depends on resources available and policies in individual countries and geographical settings. FUNDING: This review was part of doctoral thesis which was funded by University of Adelaide, Australia. en
dc.description.uri en
dc.format.medium Electronic-eCollection en
dc.language English en
dc.publisher Elsevier en
dc.relation.ispartofseries EBioMedicine en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.rights.uri en
dc.title Interventions to Improve Neonatal Health and Later Survival: An Overview of Systematic Reviews en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.ebiom.2015.05.023 en
pubs.issue 8 en
pubs.begin-page 985 en
pubs.volume 2 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 26425706 en en
pubs.end-page 1000 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 489399 en Liggins Institute en LiFePATH en
dc.identifier.eissn 2352-3964 en
pubs.record-created-at-source-date 2015-11-16 en
pubs.dimensions-id 26425706 en

Files in this item

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace