dc.contributor.author |
Ruddy, Bryan |
en |
dc.contributor.author |
McKeage, James |
en |
dc.contributor.author |
Williams, Rhys |
en |
dc.contributor.author |
Nielsen, Poul |
en |
dc.contributor.author |
Taberner, Andrew |
en |
dc.coverage.spatial |
Milan, Italy |
en |
dc.date.accessioned |
2015-11-30T02:34:55Z |
en |
dc.date.issued |
2015-08-28 |
en |
dc.identifier.citation |
37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milan, Italy, 25 Aug 2015 - 29 Aug 2015. 7341-7344. 28 Aug 2015 |
en |
dc.identifier.isbn |
978-1-4244-9270-1 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/27608 |
en |
dc.description.abstract |
We present a new design for a needle-free injector ampoule, using two concentric pistons to pressurize the fluid during the injection. The smaller, inner piston is used to provide an initial high-velocity piercing jet; it then engages the outer piston to deliver the remaining drug via a low-velocity jet. The goal of this design is to enable needle-free delivery of relatively large volumes to controlled depths in tissue, a task impractical with conventional ampoules and actuators. We demonstrate this concept by constructing a 1.2mL ampoule, measuring the jet velocity it produces in free air, and performing a set of injections into post-mortem porcine tissue. The ampoule smoothly produces the two desired phases of an injection, with a smooth transition of jet velocity as the two pistons engage. The injection is able to penetrate porcine skin to a controlled depth and deliver fluid to the subcutaneous and/or intramuscular layers, though further investigation is required to ensure that all of the fluid delivered can be retained at the desired depth. |
en |
dc.relation.ispartof |
37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.title |
A compound ampoule for large-volume controllable jet injection |
en |
dc.type |
Conference Item |
en |
dc.identifier.doi |
10.1109/EMBC.2015.7320087 |
en |
pubs.begin-page |
7341 |
en |
dc.description.version |
AM - Accepted Manuscript |
en |
dc.identifier.pmid |
26737987 |
en |
pubs.end-page |
7344 |
en |
pubs.finish-date |
2015-08-29 |
en |
pubs.start-date |
2015-08-25 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Proceedings |
en |
pubs.elements-id |
505031 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Engineering |
en |
pubs.org-id |
Engineering Science |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2015-11-16 |
en |
pubs.dimensions-id |
26737987 |
en |