dc.contributor.advisor |
Fernandez, J |
en |
dc.contributor.advisor |
Cornish, J |
en |
dc.contributor.author |
Sreenivasan, Dharshini |
en |
dc.date.accessioned |
2015-12-13T21:33:20Z |
en |
dc.date.issued |
2015 |
en |
dc.identifier.citation |
2015 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/27734 |
en |
dc.description.abstract |
In this thesis, a computational pipeline is presented which is used to assess bone failure strength in response to anabolic treatments. The pipeline was validated on a 3D printed bone sample, which underwent an Instron compression test. This pipeline was evaluated as part of three clinical studies. The first, a large scale human clinical trial on the effects of low-dose fluoride therapy in postmenopausal women. Second, a whey protein diet in a murine model which also integrated material properties from a number of different sources at different scales. Third, a computational assessment of commonly used murine controls: OVX and Sham mice. Finally, the pipeline was applied to an external collaboration which looked at the influence of Vitamin D depletion in a murine model. In all studies, our modelling pipeline was able to predict the same trends as standard clinical measures, using a double blinded design. The reported failure from the Instron test formed the basis of the yield criteria for the computational work and was also able to isolate architecture from material properties for both trabecular and cortical bone. The overall outcome from this thesis was the development, refinement and validation of a computational pipeline, which was efficient, integrates clinical work and was tested in a real clinical scenario to provide confidence in the use of computational models. |
en |
dc.publisher |
ResearchSpace@Auckland |
en |
dc.relation.ispartof |
PhD Thesis - University of Auckland |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Integrating micro-CT and computational bone mechanics to evaluate bone treatment outcomes |
en |
dc.type |
Thesis |
en |
thesis.degree.grantor |
The University of Auckland |
en |
thesis.degree.level |
Doctoral |
en |
thesis.degree.name |
PhD |
en |
dc.rights.holder |
Copyright: The Author |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.elements-id |
512970 |
en |
pubs.record-created-at-source-date |
2015-12-14 |
en |
dc.identifier.wikidata |
Q112910761 |
|