Microbiological Contamination of Drugs during Their Administration for Anesthesia in the Operating Room.

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dc.contributor.author Gargiulo, Derryn en
dc.contributor.author Mitchell, Simon en
dc.contributor.author Sheridan, Jane en
dc.contributor.author Short, TG en
dc.contributor.author Swift, Simon en
dc.contributor.author Torrie, Jocelyn en
dc.contributor.author Webster, Craig en
dc.contributor.author Merry, Alan en
dc.date.accessioned 2016-03-06T21:23:43Z en
dc.date.issued 2016 en
dc.identifier.citation Anesthesiology, 2016, 124 (4), pp. 1 - 10 en
dc.identifier.issn 0003-3022 en
dc.identifier.uri http://hdl.handle.net/2292/28390 en
dc.description.abstract Background: The aseptic techniques of anesthesiologists in the preparation and administration of injected medications have not been extensively investigated, but emerging data demonstrate that inadvertent lapses in aseptic technique may be an important contributor to surgical site and other postoperative infections. Methods: A prospective, open, microbiological audit of 303 cases in which anesthesiologists were asked to inject all bolus drugs, except propofol and antibiotics, through a 0.2-µm filter was performed. The authors cultured microorganisms, if present, from the 0.2-µm filter unit and from the residual contents of the syringes used for drawing up or administering drugs. Participating anesthesiologists rated ease of use of the filters after each case. Results: Twenty-three anesthesiologists each anesthetized up to 25 adult patients. The authors isolated microorganisms from filter units in 19 (6.3%) of 300 cases (3 cases were excluded), including Staphylococcus capitis, Staphylococcus warneri, Staphylococcus epidermidis, Staphylococcus haemolyticus, Micrococcus luteus/lylae, Corynebacterium, and Bacillus species. The authors collected used syringes at the end of each case and grew microorganisms from residual drug in 55 of these 2,318 (2.4%) syringes including all the aforementioned microorganisms and also Kocuria kristinae, Staphylococcus aureus, and Staphylococcus hominus. Participants’ average rating of ease of use of the filter units was 3.5 out of 10 (0 being very easy and 10 being very difficult). Conclusions: Microorganisms with the potential to cause infection are being injected (presumably inadvertently) into some patients during the administration of intravenous drugs by bolus during anesthesia. The relevance of this finding to postoperative infections warrants further investigation. en
dc.publisher Lippincott, Williams & Wilkins en
dc.relation.ispartofseries Anesthesiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0003-3022/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Microbiological Contamination of Drugs during Their Administration for Anesthesia in the Operating Room. en
dc.type Journal Article en
dc.identifier.doi 10.1097/ALN.0000000000001041 en
pubs.issue 4 en
pubs.begin-page 1 en
pubs.volume 124 en
dc.rights.holder Copyright: Lippincott, Williams & Wilkins en
dc.identifier.pmid 26845141 en
pubs.author-url http://anesthesiology.pubs.asahq.org/journal.aspx en
pubs.end-page 10 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 499183 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Molecular Medicine en
pubs.org-id Pharmacy en
pubs.org-id School of Medicine en
pubs.org-id Anaesthesiology en
pubs.org-id Cent Medical & Hlth Sci Educat en
dc.identifier.eissn 1528-1175 en
pubs.record-created-at-source-date 2015-09-28 en
pubs.dimensions-id 26845141 en

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