The first metatarsophalangeal joint in gout: a systematic review and meta-analysis

Show simple item record Stewart, S en Dalbeth, Nicola en Vandal, Alain en Rome, K en 2016-03-07T22:59:10Z en 2016-01 en
dc.identifier.citation BMC Musculoskeletal Disorders, 2016, 17 (1), Article number 69 en
dc.identifier.issn 1471-2474 en
dc.identifier.uri en
dc.description.abstract The aim of this review was to qualitatively synthesise studies that have investigated characteristics of the first metatarsophalangeal joint (1(st) MTP) in gout and to undertake a meta-analysis to estimate the average prevalence of acute 1(st) MTP arthritis across studies in people with gout.Studies published in English were included if they involved participants who had a diagnosis of gout and presented original findings relating to the following outcome measures associated with the 1(st) MTP: epidemiology; clinical features; structural and functional characteristics; and microscopic and imaging features.Forty-five studies were included in the qualitative synthesis. 1(st) MTP pain was a prominent feature in people with gout. People with 1(st) MTP gout reported walking- and general-disability. Structural and functional characteristics of 1(st) MTP gout included hallux valgus, osteoarthritis, and restricted joint motion. Successful crystal aspiration ranged from 81 to 91 % and positive crystal identification via microscopy ranged from 83 to 93 % in patients with a history of 1(st) MTP gout. Imaging features were common at the 1(st) MTP including the double contour sign, tophi and erosions. Eleven studies involving 2,325 participants were included in the meta-analysis, providing an estimate of the average prevalence of acute 1(st) MTP arthritis across studies of 73 % (95 % prediction interval 40-92 %; range 48-97 %; I(2) = 93 %).1(st) MTP acute arthritis is highly prevalent in people with gout and has a substantial impact on patient-reported pain and disability. Gout affects the structure and function of the 1(st) MTP. Microscopic and imaging studies have demonstrated crystal deposition and joint damage at the 1(st) MTP in people with gout. en
dc.format.medium Electronic en
dc.language eng en
dc.publisher BioMed Central en
dc.relation.ispartofseries BMC Musculoskeletal Disorders en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.title The first metatarsophalangeal joint in gout: a systematic review and meta-analysis en
dc.type Journal Article en
dc.identifier.doi 10.1186/s12891-016-0919-9 en
pubs.issue 1 en
pubs.volume 17 en
dc.description.version VoR - Version of Record en
dc.rights.holder Copyright: BioMed Central en
dc.identifier.pmid 26864742 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 523114 en Medical and Health Sciences en School of Medicine en Medicine Department en Science en Statistics en
dc.identifier.eissn 1471-2474 en
pubs.number 69 en
pubs.record-created-at-source-date 2016-03-08 en
pubs.dimensions-id 26864742 en

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