dc.contributor.author |
Galinsky, Robert |
en |
dc.contributor.author |
Davidson, Joanne |
en |
dc.contributor.author |
Drury, Paul |
en |
dc.contributor.author |
Wassink, Guido |
en |
dc.contributor.author |
Lear, Christopher |
en |
dc.contributor.author |
van den Heuij, LG |
en |
dc.contributor.author |
Gunn, Alistair |
en |
dc.contributor.author |
Bennet, Laura |
en |
dc.date.accessioned |
2016-03-14T03:59:18Z |
en |
dc.date.issued |
2016-03-01 |
en |
dc.identifier.citation |
Journal of Physiology, 2016, 594 (5), pp. 1281 - 1293 (13) |
en |
dc.identifier.issn |
0022-3751 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/28452 |
en |
dc.description.abstract |
Magnesium sulphate is a standard therapy for eclampsia in pregnancy and is widely recommended for perinatal neuroprotection during threatened preterm labour. MgSO4 is a vasodilator and negative inotrope. Therefore the aim of this study was to investigate the effect of MgSO4 on the cardiovascular and cerebrovascular responses of the preterm fetus to asphyxia. Fetal sheep were instrumented at 98 ± 1 days of gestation (d; term = 147 d). At 104 d, unanaesthetised fetuses were randomly assigned to receive an intravenous infusion of MgSO4 (n = 6) or saline (n = 9). At 105 d all fetuses underwent umbilical cord occlusion for 25 minutes. Before occlusion, MgSO4 treatment reduced heart rate and increased femoral blood flow and vascular conductance compared to controls. During occlusion, carotid and femoral arterial conductance and blood flows were higher in MgSO4 treated fetuses than controls. After occlusion, fetal heart rate was lower and carotid and femoral arterial conductance and blood flows were higher in MgSO4 treated fetuses than controls. Femoral arterial waveform height and width were increased during MgSO4 infusion, consistent with increased stroke volume. MgSO4 did not alter the fetal neurophysiological or nuchal electromyographic responses to asphyxia. These data demonstrate that a clinically comparable dose of MgSO4 increased FBF and stroke volume without impairing MAP or CaBF during and immediately after profound asphyxia. Thus, MgSO4 may increase perfusion of peripheral vascular beds during adverse perinatal events. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
English |
en |
dc.relation.ispartofseries |
Journal of Physiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0022-3751/
http://olabout.wiley.com/WileyCDA/Section/id-820227.html |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Magnesium sulphate and cardiovascular and cerebrovascular adaptations to asphyxia in preterm fetal sheep |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1113/jp270614 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
1281 |
en |
pubs.volume |
594 |
en |
dc.description.version |
AM - Accepted Manuscript |
en |
dc.identifier.pmid |
26077461 |
en |
pubs.author-url |
http://onlinelibrary.wiley.com/doi/10.1113/JP270614/abstract |
en |
pubs.end-page |
1293 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
488764 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
dc.identifier.eissn |
1469-7793 |
en |
pubs.record-created-at-source-date |
2015-06-22 |
en |
pubs.dimensions-id |
26077461 |
en |