dc.contributor.author |
Lear, Christopher |
en |
dc.contributor.author |
Galinsky, Robert |
en |
dc.contributor.author |
Wassink, Guido |
en |
dc.contributor.author |
Mitchell, CJ |
en |
dc.contributor.author |
Davidson, Joanne |
en |
dc.contributor.author |
Westgate, JA |
en |
dc.contributor.author |
Bennet, Laura |
en |
dc.contributor.author |
Gunn, Alistair |
en |
dc.date.accessioned |
2016-03-14T22:40:23Z |
en |
dc.date.available |
2015-04-07 |
en |
dc.date.issued |
2016-03-01 |
en |
dc.identifier.citation |
Journal of Physiology, 2016, 594 (5), pp. 1265 - 1277 (13) |
en |
dc.identifier.issn |
0022-3751 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/28457 |
en |
dc.description.abstract |
Changes in fetal heart rate variability (FHRV) and ST segment elevation (measured as the T/QRS ratio) are used to evaluate fetal adaptation to labour. The sympathetic nervous system (SNS) is an important contributor to FHRV under healthy normoxic conditions, and is critical for rapid support of blood pressure during brief labour-like asphyxia. However, although it has been assumed that SNS activity contributes to FHRV during labour; this has never been tested, and it is unclear whether the SNS contributes to the rapid increase in T/QRS ratio during brief asphyxia. Thirteen chronically instrumented fetal sheep at 0.85 of gestation received either chemical sympathectomy with 6-hydroxydopamine (6-OHDA; n = 6) or sham treatment (control; n = 7), followed 4-5 days later by 2 minute episodes of complete umbilical cord occlusion repeated every 5 minutes for up to 4 hours, or until mean arterial blood pressure fell to < 20 mmHg for two successive occlusions. FHRV was decreased before occlusions in the 6-OHDA group (p<0.05) and 2 to 4.5 hours during recovery after occlusions (p<0.05) compared to the control group. During each occlusion there was a rapid increase in T/QRS ratio. Between successive occlusions the T/QRS ratio rapidly returned to baseline, and FHRV increased above baseline in both groups (p<0.05), with no significant effect of sympathectomy on FHRV or T/QRS ratio. In conclusion, these data show that SNS activity does not mediate the increase in FHRV between repeated episodes of brief umbilical cord occlusion or the transient increase in T/QRS ratio during occlusions. |
en |
dc.description.uri |
http://www.ncbi.nlm.nih.gov/pubmed/25864517 |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
English |
en |
dc.relation.ispartofseries |
Journal of Physiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0022-3751/
http://olabout.wiley.com/WileyCDA/Section/id-820227.html |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Sympathetic neural activation does not mediate heart rate variability during repeated brief umbilical cord occlusions in near-term fetal sheep |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1113/JP270125 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
1265 |
en |
pubs.volume |
594 |
en |
dc.identifier.pmid |
25864517 |
en |
pubs.author-url |
http://onlinelibrary.wiley.com/doi/10.1113/JP270125/abstract |
en |
pubs.end-page |
1277 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
485995 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
dc.identifier.eissn |
1469-7793 |
en |
pubs.record-created-at-source-date |
2015-06-30 |
en |
pubs.dimensions-id |
25864517 |
en |