dc.contributor.author |
Robinson, Thomas |
en |
dc.contributor.author |
Elley, Carolyn |
en |
dc.contributor.author |
Kenealy, Timothy |
en |
dc.contributor.author |
Drury, PL |
en |
dc.date.accessioned |
2016-05-02T02:47:12Z |
en |
dc.date.issued |
2015-06 |
en |
dc.identifier.citation |
Diabetes Research and Clinical Practice, 2015, 108 (3), pp. 482 - 488 |
en |
dc.identifier.issn |
1872-8227 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/28709 |
en |
dc.description.abstract |
Type 2 diabetes is common and is associated with an approximate 80% increase in the rate of mortality. Management decisions may be assisted by an estimate of the patient's absolute risk of adverse outcomes, including death. This study aimed to derive a predictive risk model for all-cause mortality in type 2 diabetes.We used primary care data from a large national multi-ethnic cohort of patients with type 2 diabetes in New Zealand and linked mortality records to develop a predictive risk model for 5-year risk of mortality. We then validated this model using information from a separate cohort of patients with type 2 diabetes.26,864 people were included in the development cohort with a median follow up time of 9.1 years. We developed three models initially using demographic information and then progressively more clinical detail. The final model, which also included markers of renal disease, proved to give best prediction of all-cause mortality with a C-statistic of 0.80 in the development cohort and 0.79 in the validation cohort (7610 people) and was well calibrated. Ethnicity was a major factor with hazard ratios of 1.37 for indigenous Maori, 0.41 for East Asian and 0.55 for Indo Asian compared with European (P<0.001).We have developed a model using information usually available in primary care that provides good assessment of patient's risk of death. Results are similar to models previously published from smaller cohorts in other countries and apply to a wider range of patient ethnic groups. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Diabetes Research and Clinical Practice |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0168-8227/
https://www.elsevier.com/about/company-information/policies/sharing |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
en |
dc.subject |
Humans |
en |
dc.subject |
Diabetes Mellitus, Type 2 |
en |
dc.subject |
Incidence |
en |
dc.subject |
Cause of Death |
en |
dc.subject |
Survival Rate |
en |
dc.subject |
Risk Assessment |
en |
dc.subject |
Risk Factors |
en |
dc.subject |
Models, Theoretical |
en |
dc.subject |
Middle Aged |
en |
dc.subject |
Ethnic Groups |
en |
dc.subject |
New Zealand |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.title |
Development and validation of a predictive risk model for all-cause mortality in type 2 diabetes |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.diabres.2015.02.015 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
482 |
en |
pubs.volume |
108 |
en |
dc.description.version |
AM - Accepted manuscript |
en |
dc.rights.holder |
Copyright:
Elsevier |
en |
dc.identifier.pmid |
25869581 |
en |
pubs.end-page |
488 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
486563 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Population Health |
en |
pubs.org-id |
Gen.Practice& Primary Hlthcare |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
dc.identifier.eissn |
1872-8227 |
en |
pubs.record-created-at-source-date |
2016-05-02 |
en |
pubs.dimensions-id |
25869581 |
en |