dc.contributor.author |
Littlejohn, MD |
en |
dc.contributor.author |
Henty, Kristen |
en |
dc.contributor.author |
Tiplady, K |
en |
dc.contributor.author |
Johnson, T |
en |
dc.contributor.author |
Harland, C |
en |
dc.contributor.author |
Lopdell, Thomas |
en |
dc.contributor.author |
Sherlock, RG |
en |
dc.contributor.author |
Li, W |
en |
dc.contributor.author |
Lukefahr, SD |
en |
dc.contributor.author |
Shanks, BC |
en |
dc.contributor.author |
Garrick, DJ |
en |
dc.contributor.author |
Snell, Russell |
en |
dc.contributor.author |
Spelman, RJ |
en |
dc.contributor.author |
Davis, SR |
en |
dc.date.accessioned |
2016-05-27T04:34:02Z |
en |
dc.date.available |
2014-11-13 |
en |
dc.date.issued |
2014-12-18 |
en |
dc.identifier.citation |
Nature communications, 2014, 5, 5861 |
en |
dc.identifier.issn |
2041-1723 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/28918 |
en |
dc.description.abstract |
Lactation, hair development and homeothermy are characteristic evolutionary features that define mammals from other vertebrate species. Here we describe the discovery of two autosomal dominant mutations with antagonistic, pleiotropic effects on all three of these biological processes, mediated through the prolactin signalling pathway. Most conspicuously, mutations in prolactin (PRL) and its receptor (PRLR) have an impact on thermoregulation and hair morphology phenotypes, giving prominence to this pathway outside of its classical roles in lactation. |
en |
dc.description.uri |
http://www.ncbi.nlm.nih.gov/pubmed/25519203 |
en |
dc.format.medium |
Electronic |
en |
dc.language |
English |
en |
dc.relation.ispartofseries |
Nature communications |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/2041-1723/
http://www.nature.com/ncomms/open_access/index.html |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Hair |
en |
dc.subject |
Skin |
en |
dc.subject |
Animals |
en |
dc.subject |
Cattle |
en |
dc.subject |
Humans |
en |
dc.subject |
Prolactin |
en |
dc.subject |
Receptors, Prolactin |
en |
dc.subject |
Body Temperature |
en |
dc.subject |
Signal Transduction |
en |
dc.subject |
Gene Expression |
en |
dc.subject |
Amino Acid Sequence |
en |
dc.subject |
Base Sequence |
en |
dc.subject |
Body Temperature Regulation |
en |
dc.subject |
Homeostasis |
en |
dc.subject |
Lactation |
en |
dc.subject |
Genotype |
en |
dc.subject |
Phenotype |
en |
dc.subject |
Mutation |
en |
dc.subject |
Molecular Sequence Data |
en |
dc.subject |
Female |
en |
dc.subject |
Genetic Pleiotropy |
en |
dc.title |
Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1038/ncomms6861 |
en |
pubs.volume |
5 |
en |
dc.identifier.pmid |
25519203 |
en |
pubs.author-url |
http://www.nature.com/ncomms/2014/141218/ncomms6861/full/ncomms6861.html |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
471267 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
dc.identifier.eissn |
2041-1723 |
en |
pubs.number |
5861 |
en |
pubs.record-created-at-source-date |
2016-05-27 |
en |
pubs.dimensions-id |
25519203 |
en |