dc.contributor.author |
Kao, CH |
en |
dc.contributor.author |
Bishop, Karen |
en |
dc.contributor.author |
Xu, Y |
en |
dc.contributor.author |
Han, DY |
en |
dc.contributor.author |
Murray, PM |
en |
dc.contributor.author |
Marlow, GJ |
en |
dc.contributor.author |
Ferguson, Lynnette |
en |
dc.date.accessioned |
2016-06-13T02:32:46Z |
en |
dc.date.available |
2015-10-24 |
en |
dc.date.issued |
2016-02-16 |
en |
dc.identifier.citation |
Genomics insights, 2016, 9 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/29043 |
en |
dc.description.abstract |
Ganoderma lucidum (lingzhi) has been used for the general promotion of health in Asia for many centuries. The common method of consumption is to boil lingzhi in water and then drink the liquid. In this study, we examined the potential anticancer activities of G. lucidum submerged in two commonly consumed forms of alcohol in East Asia: malt whiskey and rice wine. The anticancer effect of G. lucidum, using whiskey and rice wine-based extraction methods, has not been previously reported. The growth inhibition of G. lucidum whiskey and rice wine extracts on the prostate cancer cell lines, PC3 and DU145, was determined. Using Affymetrix gene expression assays, several biologically active pathways associated with the anticancer activities of G. lucidum extracts were identified. Using gene expression analysis (real-time polymerase chain reaction [RT-PCR]) and protein analysis (Western blotting), we confirmed the expression of key genes and their associated proteins that were initially identified with Affymetrix gene expression analysis. |
en |
dc.description.uri |
http://www.ncbi.nlm.nih.gov/pubmed/27006591 |
en |
dc.format.medium |
Electronic-eCollection |
en |
dc.language |
English |
en |
dc.relation.ispartofseries |
Genomics insights |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1178-6310/
http://www.la-press.com/author_resources.php?folder_id=120#pagelink_663 |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
http://creativecommons.org/licenses/by-nc/3.0/ |
en |
dc.subject |
Ganoderma lucidum |
en |
dc.subject |
prostate cancer |
en |
dc.subject |
microarray |
en |
dc.subject |
Western blot |
en |
dc.subject |
PC3 |
en |
dc.subject |
DU145 |
en |
dc.title |
Identification of Potential Anticancer Activities of Novel Ganoderma lucidum Extracts Using Gene Expression and Pathway Network Analysis |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.4137/GEI.S32477 |
en |
pubs.volume |
9 |
en |
dc.description.version |
VoR - Version of Record |
en |
dc.identifier.pmid |
27006591 |
en |
pubs.author-url |
http://www.la-press.com/identification-of-potential-anticancer-activities-of-novel-ganoderma-l-article-a5392 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
525672 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
dc.identifier.eissn |
1178-6310 |
en |
pubs.record-created-at-source-date |
2016-06-13 |
en |
pubs.dimensions-id |
27006591 |
en |