dc.contributor.author |
Lenihan-Geels, G |
en |
dc.contributor.author |
Bishop, Karen |
en |
dc.contributor.author |
Ferguson, Lynnette |
en |
dc.date.accessioned |
2016-06-13T03:09:48Z |
en |
dc.date.available |
2016-02-02 |
en |
dc.date.issued |
2016-02-15 |
en |
dc.identifier.citation |
Journal of clinical medicine, 2016, 5 (2), 25 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/29046 |
en |
dc.description.abstract |
Dietary inclusion of fish and fish supplements as a means to improve cancer prognosis and prevent tumour growth is largely controversial. Long chain omega-3 polyunsaturated fatty acids (LCn-3 PUFA), eicosapentaenoic acid and docosahexaenoic acid, may modulate the production of inflammatory eicosanoids, thereby influencing local inflammatory status, which is important in cancer development. Although in vitro studies have demonstrated inhibition of tumour cell growth and proliferation by LCn-3 PUFA, results from human studies have been mainly inconsistent. Genes involved in the desaturation of fatty acids, as well as the genes encoding enzymes responsible for eicosanoid production, are known to be implicated in tumour development. This review discusses the current evidence for an interaction between genetic polymorphisms and dietary LCn-3 PUFA in the risk for breast, prostate and colorectal cancers, in regards to inflammation and eicosanoid synthesis. |
en |
dc.description.uri |
http://www.ncbi.nlm.nih.gov/pubmed/26891335 |
en |
dc.format.medium |
Electronic |
en |
dc.language |
English |
en |
dc.relation.ispartofseries |
Journal of clinical medicine |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/2077-0383/
http://www.mdpi.com/about/openaccess |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
en |
dc.subject |
long chain omega-3 polyunsaturated fatty acid |
en |
dc.subject |
cancer |
en |
dc.subject |
single nucleotide polymorphism |
en |
dc.subject |
eicosanoids |
en |
dc.subject |
genotype |
en |
dc.title |
Cancer Risk and Eicosanoid Production: Interaction between the Protective Effect of Long Chain Omega-3 Polyunsaturated Fatty Acid Intake and Genotype |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.3390/jcm5020025 |
en |
pubs.issue |
2 |
en |
pubs.volume |
5 |
en |
dc.description.version |
VoR - Version of Record |
en |
dc.identifier.pmid |
26891335 |
en |
pubs.author-url |
http://www.mdpi.com/2077-0383/5/2/25 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
524151 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
dc.identifier.eissn |
2077-0383 |
en |
dc.identifier.pii |
E25 |
en |
pubs.number |
25 |
en |
pubs.record-created-at-source-date |
2016-06-13 |
en |
pubs.dimensions-id |
26891335 |
en |