Heterogeneity of muscle sizes in the lower limbs of children with cerebral palsy

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dc.contributor.author Handsfield, Geoffrey en
dc.contributor.author Meyer, CH en
dc.contributor.author Abel, MF en
dc.contributor.author Blemker, SS en
dc.date.accessioned 2016-06-17T00:59:36Z en
dc.date.issued 2016-06 en
dc.identifier.citation Muscle & Nerve, 2016, 53 (6), pp. 933 - 945 en
dc.identifier.issn 0148-639X en
dc.identifier.uri http://hdl.handle.net/2292/29111 en
dc.description.abstract Introduction Cerebral palsy (CP) is associated with reduced muscle volumes, but previous studies have reported deficits in only a small number of muscles. The extent of volume deficits across lower limb muscles is not known. This study presents an imaging-based assessment of muscle volume and length deficits in 35 lower limb muscles. Methods We imaged and segmented 35 muscles in 10 subjects with CP and 8 typically developing (TD) controls using MRI. Muscle volumes were normalized, and Z-scores were computed using TD data. Volume Z-scores and percent deficits in volume, length, and cross-sectional area are reported. Results Muscle volumes are 20% lower, on average, for subjects with CP. Volume deficits differ significantly between muscles (12%–43%) and display significant heterogeneity across subjects. Distal muscles, especially the soleus, are commonly and severely small. Conclusions Heterogeneity across muscles and across subjects reinforces the subject specificity of CP and the need for individualized treatment planning. en
dc.relation.ispartofseries Muscle & Nerve en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0148-639X/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Heterogeneity of muscle sizes in the lower limbs of children with cerebral palsy en
dc.type Journal Article en
dc.identifier.doi 10.1002/mus.24972 en
pubs.issue 6 en
pubs.begin-page 933 en
pubs.volume 53 en
dc.description.version AM - Accepted Manuscript en
dc.identifier.pmid 26565390 en
pubs.end-page 945 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 511680 en
pubs.org-id Bioengineering Institute en
pubs.record-created-at-source-date 2016-06-17 en
pubs.dimensions-id 26565390 en


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