Absolute cardiovascular risk and GP decision-making in TIA and minor stroke

Show simple item record

dc.contributor.author Clarey, J en
dc.contributor.author Lasserson, D en
dc.contributor.author Levi, C en
dc.contributor.author Parsons, M en
dc.contributor.author Dewey, H en
dc.contributor.author Barber, Peter en
dc.contributor.author Quain, D en
dc.contributor.author McElduff, P en
dc.contributor.author Sales, M en
dc.contributor.author Magin, P en
dc.date.accessioned 2016-06-26T23:24:11Z en
dc.date.issued 2014 en
dc.identifier.citation Family Practice, 2014, 31 (6), pp. 664 - 669 en
dc.identifier.issn 0263-2136 en
dc.identifier.uri http://hdl.handle.net/2292/29172 en
dc.description.abstract Background. Transient ischaemic attacks (TIA) and minor strokes (TIAMS) have the same pathophysiological mechanism as stroke and carry a high risk of recurrent ischaemic events. Diagnosis of TIAMS can be challenging and often occurs in general practice. Absolute cardiovascular risk (ACVR) is recommended as the basis for vascular risk management. Consideration of cardiovascular risk in TIAMS diagnosis has been recommended but its utility is not established. Objectives. Firstly, to document the ACVR of patients with incident TIAMS and with TIAMS-mimics. Secondly, to evaluate the utility of ACVR calculation in informing the initial diagnosis of TIAMS. Methods. The International comparison of Systems of care and patient outcomes in minor Stroke and TIA (InSiST) study is an inception cohort study of patients of 17 Australian general practices presenting as possible TIAMS. An expert panel determines whether participants have had TIAMS or TIAMS-mimics. ACVR was calculated at baseline for each participating patient. In this cross-sectional baseline analysis, ACVR of TIAMS and TIAMS-mimics were compared univariately and, also, when adjusted for age and sex. The diagnostic utility of ACVR was evaluated via receiver operating characteristic (ROC) curves. Results. Of 179 participants, 87 were adjudicated as TIAMS. The presence of motor and speech symptoms and body mass index were associated with a diagnosis of TIAMS. ACVR was associated with TIAMS diagnosis on univariate analysis, but not when age- and sex-adjusted. ACVR did not significantly improve area under ROC curves beyond that of age and sex. Conclusion. In patients presenting with transient or minor neurological symptoms, calculation of ACVR did not improve diagnostic accuracy for TIAMS beyond that of age and sex. en
dc.description.uri http://fampra.oxfordjournals.org/ en
dc.publisher Oxford University Press en
dc.relation.ispartofseries Family Practice en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0263-2136/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Absolute cardiovascular risk and GP decision-making in TIA and minor stroke en
dc.type Journal Article en
dc.identifier.doi 10.1093/fampra/cmu054 en
pubs.issue 6 en
pubs.begin-page 664 en
pubs.volume 31 en
dc.rights.holder Copyright: Oxford University Press en
dc.identifier.pmid 25208544 en
pubs.author-url http://fampra.oxfordjournals.org/content/31/6/664 en
pubs.end-page 669 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 448841 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
dc.identifier.eissn 1460-2229 en
pubs.record-created-at-source-date 2014-08-07 en
pubs.dimensions-id 25208544 en

Files in this item

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace