dc.contributor.author |
Bisht, Rohit |
en |
dc.contributor.author |
Jaiswal, Jagdish |
en |
dc.contributor.author |
Chen, Ying-Shan |
en |
dc.contributor.author |
Jin, Jianyong |
en |
dc.contributor.author |
Rupenthal, Ilva |
en |
dc.date.accessioned |
2016-07-06T23:52:47Z |
en |
dc.date.issued |
2016 |
en |
dc.identifier.citation |
Expert Opinion on Drug Delivery, 2016, 13 (7), pp. 953 - 962 |
en |
dc.identifier.issn |
1742-5247 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/29334 |
en |
dc.description.abstract |
Introduction: Frequent intravitreal injections are currently the preferred treatment method for diseases affecting the posterior segment of the eye. However, these repeated injections have been associated with pain, risk of infection, hemorrhages, retinal detachment and high treatment costs. To overcome these limitations, light-responsive in situ forming injectable implants (ISFIs) may emerge as novel systems providing site-specific controlled drug delivery to the retinal tissues with great accuracy, safety, minimal invasiveness and high cost efficiency. Area covered: Complex ocular barriers, routes for drug delivery, types of injectable implants, ocular application of light and benefits of light-responsive systems are discussed with regards to challenges and strategies employed for effective drug delivery to the posterior segment of the eye. In particular, we have highlighted photoresponsive moieties, photopolymerization mechanisms and different development strategies with their limitations as well as recent advancements in the field. Expert opinion: Biodegradable light-responsive ISFIs are promising drug delivery systems that have shown a high degree of biocompatibility with sustained drug release in a number of applications. However, their use in intravitreal drug delivery is still in the very early stages. Issues related to the biocompatibility of the photoinitiator and the elimination of photo-degraded by-products from the ocular tissues need careful consideration, not only from a chemistry standpoint, but also from a biological perspective to improve the suitability of these systems for clinical applications. |
en |
dc.description.uri |
http://www.tandfonline.com/toc/iedd20/current |
en |
dc.publisher |
Taylor & Francis: STM, Behavioural Science and Public Health Titles |
en |
dc.relation.ispartofseries |
Expert Opinion on Drug Delivery |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1742-5247/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Light-responsive in situ forming injectable implants for effective drug delivery to the posterior segment of the eye |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1517/17425247.2016.1163334 |
en |
pubs.issue |
7 |
en |
pubs.begin-page |
953 |
en |
pubs.volume |
13 |
en |
dc.rights.holder |
Copyright: Informa UK Limited. Taylor & Francis Group |
en |
dc.identifier.pmid |
26967153 |
en |
pubs.author-url |
http://www.tandfonline.com/doi/full/10.1517/17425247.2016.1163334 |
en |
pubs.end-page |
962 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.elements-id |
524703 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Ophthalmology Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Chemistry |
en |
dc.identifier.eissn |
1744-7593 |
en |
pubs.record-created-at-source-date |
2016-07-07 |
en |
pubs.dimensions-id |
26967153 |
en |