Replicated analysis of the genetic architecture of quantitative traits in two wild great tit populations

Show simple item record Santure, Anna en Poissant, J en De Cauwer, I en van Oers, K en Robinson, MR en Quinn, JL en Groenen, MAM en Visser, ME en Sheldon, BC en Slate, J en 2016-07-14T04:44:59Z en 2015-12 en
dc.identifier.citation Molecular Ecology, 2015, 24 (24), pp. 6148 - 6162 en
dc.identifier.issn 0962-1083 en
dc.identifier.uri en
dc.description.abstract Currently, there is much debate on the genetic architecture of quantitative traits in wild populations. Is trait variation influenced by many genes of small effect or by a few genes of major effect? Where is additive genetic variation located in the genome? Do the same loci cause similar phenotypic variation in different populations? Great tits (Parus major) have been studied extensively in long-term studies across Europe and consequently are considered an ecological 'model organism'. Recently, genomic resources have been developed for the great tit, including a custom SNP chip and genetic linkage map. In this study, we used a suite of approaches to investigate the genetic architecture of eight quantitative traits in two long-term study populations of great tits-one in the Netherlands and the other in the United Kingdom. Overall, we found little evidence for the presence of genes of large effects in either population. Instead, traits appeared to be influenced by many genes of small effect, with conservative estimates of the number of contributing loci ranging from 31 to 310. Despite concordance between population-specific heritabilities, we found no evidence for the presence of loci having similar effects in both populations. While population-specific genetic architectures are possible, an undetected shared architecture cannot be rejected because of limited power to map loci of small and moderate effects. This study is one of few examples of genetic architecture analysis in replicated wild populations and highlights some of the challenges and limitations researchers will face when attempting similar molecular quantitative genetic studies in free-living populations. en
dc.description.uri en
dc.publisher John Wiley & Sons Ltd en
dc.relation.ispartofseries Molecular Ecology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
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dc.title Replicated analysis of the genetic architecture of quantitative traits in two wild great tit populations en
dc.type Journal Article en
dc.identifier.doi 10.1111/mec.13452 en
pubs.issue 24 en
pubs.begin-page 6148 en
pubs.volume 24 en
dc.description.version VoR – Version of Record en
dc.rights.holder Copyright: The Authors en
dc.identifier.pmid 26661500 en en
pubs.end-page 6162 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 515699 en Science en Biological Sciences en
dc.identifier.eissn 1365-294X en
pubs.record-created-at-source-date 2016-07-14 en
pubs.dimensions-id 26661500 en

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