dc.contributor.author |
Jung, Eunkyung |
en |
dc.contributor.author |
Leung, Yee Fun |
en |
dc.contributor.author |
Barker, David |
en |
dc.date.accessioned |
2016-07-19T00:04:46Z |
en |
dc.date.issued |
2016-07-01 |
en |
dc.identifier.citation |
Bioorganic and Medicinal Chemistry Letters, 2016, 26 (13), pp. 3001 - 3005 |
en |
dc.identifier.issn |
0960-894X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/29491 |
en |
dc.description.abstract |
A series of pyrrole analogues of combretastatin (CA-4) were synthesized and tested for their anti-proliferative activity. The highly diastereoselective acyl-Claisen rearrangement was used to provide 2,3-syn disubstituted morpholine amides which were used as precursors for the various analogues. This synthesis allows for the preparation of 1,2- and 2,3-diaryl-1H-pyrroles which are both geometrically similar to CA-4. These pyrrolic analogues were tested for their anti-proliferative activity against two human cell lines, K562 and MDA-MB-231 with 2,3-diaryl-1H-pyrrole 35 exhibiting the most potent activity with IC50 value of 0.07μM against MDA-MB-231 cell line. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Bioorganic and Medicinal Chemistry Letters |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Synthesis and biological activity of pyrrole analogues of combretastatin A-4 |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.bmcl.2016.05.026 |
en |
pubs.issue |
13 |
en |
pubs.begin-page |
3001 |
en |
pubs.volume |
26 |
en |
dc.rights.holder |
Copyright:
Elsevier |
en |
dc.identifier.pmid |
27212068 |
en |
pubs.end-page |
3005 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
528994 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Chemistry |
en |
dc.identifier.eissn |
1464-3405 |
en |
pubs.record-created-at-source-date |
2016-07-19 |
en |
pubs.dimensions-id |
27212068 |
en |