Rocuronium pharmacokinetics and pharmacodynamics in the adductor pollicis and masseter muscles

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dc.contributor.author Vega, EA en
dc.contributor.author Ibacache, ME en
dc.contributor.author Anderson, Brian en
dc.contributor.author Holford, Nicholas en
dc.contributor.author Nazar, CE en
dc.contributor.author Solari, S en
dc.contributor.author Allende, FA en
dc.contributor.author Cortínez, LI en
dc.date.accessioned 2016-07-22T04:41:20Z en
dc.date.issued 2016-07 en
dc.identifier.citation Acta Anaesthesiologica Scandinavica, 2016, 60 (6), pp. 734 - 746 en
dc.identifier.issn 0001-5172 en
dc.identifier.uri http://hdl.handle.net/2292/29558 en
dc.description.abstract Background: The aim of this study was to characterize the dose-effect relationship of rocuronium at the adductor pollicis and masseter muscles. Methods: Ten, ASA I, adult patients, received a bolus dose of rocuronium 0.3 mg/kg during propofol based anesthesia. Train-of-four (TOF) was simultaneously monitored at the masseter and the adductor pollicis muscles until recovery. Rocuronium arterial serum concentrations were measured during 120 min. The first twitch of the TOF response was used to characterize the time-effect profile of both muscles using pharmacokinetic-pharmacodynamic analysis in NONMEM. A decrease in NONMEM objective function (∆OFV) of 3.84 points for an added parameter was considered significant at the 0.05 level. Results: Onset time at the masseter (mean ± SD, 1.5 ± 0.9 min) was faster than at the adductor pollicis (2.7 ± 1.4 min, P < 0.05). Recovery, measured as the time to TOF ratio = 0.9 was similar between muscles 29.9 ± 6.7 (adductor pollicis) vs. 29.3 ± 8.1 (masseter). (P = 0.77). The estimated pharmacodynamic parameters [mean (95% CI)] of the adductor pollicis muscle and the masseter muscle were; plasma effect-site equilibration half-time (teq) 3.25 (2.34, 3.69) min vs. 2.86 (1.83, 3.29) min, (∆OFV 383.665); Ce50 of 1.24 (1.13, 1.56) mg/l vs. 1.19 (1.00, 1.21) mg/l, (∆OFV 184.284); Hill coefficient of 3.97 (3.82, 5.62) vs. 4.68 (3.83, 5.71), (∆OFV 78.906). Conclusions: We found that the masseter muscle has faster onset of blockade and similar recovery profile than adductor pollicis muscle. These findings were best, explained by a faster plasma effect-site equilibration of the masseter muscle to rocuronium. en
dc.description.uri http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1399-6576/ en
dc.publisher Wiley en
dc.relation.ispartofseries Acta Anaesthesiologica Scandinavica en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0001-5172/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Rocuronium pharmacokinetics and pharmacodynamics in the adductor pollicis and masseter muscles en
dc.type Journal Article en
dc.identifier.doi 10.1111/aas.12703 en
pubs.issue 6 en
pubs.begin-page 734 en
pubs.volume 60 en
dc.rights.holder Copyright: Wiley en
dc.identifier.pmid 26899676 en
pubs.author-url http://onlinelibrary.wiley.com/enhanced/doi/10.1111/aas.12703 en
pubs.end-page 746 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 524071 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Pharmacology en
pubs.org-id School of Medicine en
pubs.org-id Anaesthesiology en
dc.identifier.eissn 1399-6576 en
pubs.record-created-at-source-date 2016-07-22 en
pubs.dimensions-id 26899676 en


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