Body Mass Index Is Positively Associated with Endometrial Cancer in Chinese Women, Especially Prior to Menopause

Show simple item record

dc.contributor.author Gao, Y en
dc.contributor.author Dai, X en
dc.contributor.author Chen, L en
dc.contributor.author Lee, Arier en
dc.contributor.author Tong, M en
dc.contributor.author Wise, Michelle en
dc.contributor.author Chen, Qi en
dc.date.accessioned 2016-08-03T02:56:58Z en
dc.date.available 2016-04-26 en
dc.date.issued 2016-06-06 en
dc.identifier.citation Journal of Cancer, 2016, 7 (9), pp. 1169 - 1173 en
dc.identifier.uri http://hdl.handle.net/2292/29771 en
dc.description.abstract Obesity is a well-known risk factor for developing endometrial cancer. However, the incidence and survival rate of endometrial cancer are associated with ethnicity and geographical area. In addition, whether menopausal status is associated with developing endometrial cancer in obese women and whether obesity is associated with subtypes of endometrial cancer have not been fully investigated. Here, we investigated the effect of BMI on developing endometrial cancer in Chinese women taking into account menopausal status and cancer subtypes.Data on 1,127 women with endometrial cancer including body mass index (BMI), age at diagnosis, parity, menopausal status and cancer subtype were collected from the largest obstetrics & gynaecology hospital in China and analysed.After adjusting for age and parity, the odds for developing endometrial cancer in overweight or obese perimenopausal women was significantly higher than that in women with normal weight (OR=2.6 with 95%CI:1.9-3.5, and OR=3.5 with 95%CI: 2.2-5.4, respectively). The odds of developing endometrial cancer in overweight postmenopausal women were significantly higher than that in women who were normal weight (OR=2.4 with 95%CI: 1.8-3.1), however this was not the case for obese postmenopausal women. We further found that BMI, menopausal status, age and parity were not associated with subtypes of endometrial cancer.Our data demonstrate that obesity is positively associated with the incidence of developing endometrial cancer in Chinese women, with more significant effects in perimenopausal women. en
dc.description.uri http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911885/ en
dc.format.medium Electronic-eCollection en
dc.language English en
dc.publisher Ivyspring en
dc.relation.ispartofseries Journal of Cancer en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1837-9664/ http://www.jcancer.org/ms/terms en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject BMI en
dc.subject endometrial cancer en
dc.subject menopause en
dc.subject menopause en
dc.subject type I and type II en
dc.subject Chinese women en
dc.title Body Mass Index Is Positively Associated with Endometrial Cancer in Chinese Women, Especially Prior to Menopause en
dc.type Journal Article en
dc.identifier.doi 10.7150/jca.15037 en
pubs.issue 9 en
pubs.begin-page 1169 en
pubs.volume 7 en
dc.description.version VoR - Version of Record en
dc.identifier.pmid 27326261 en
pubs.author-url http://www.jcancer.org/v07p1169.htm en
pubs.end-page 1173 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 531430 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Population Health en
pubs.org-id Epidemiology & Biostatistics en
pubs.org-id School of Medicine en
pubs.org-id Obstetrics and Gynaecology en
dc.identifier.eissn 1837-9664 en
pubs.record-created-at-source-date 2016-08-03 en
pubs.dimensions-id 27326261 en


Files in this item

Find Full text

This item appears in the following Collection(s)

Show simple item record

Share

Search ResearchSpace


Browse

Statistics