Maternal insulin sensitivity in midpregnancy does not determine birth weight after embryo transfer between large and small breed sheep

Show simple item record Oliver, Mark en Jaquiery, Anne en Kenyon, PR en Pain, SJ en Jenkinson, CM en Blair, HT en Behrensdorf Derraik, Jose en Bloomfield, Francis en 2016-08-04T00:35:16Z en 2015-01 en
dc.identifier.citation Domestic Animal Endocrinology, 2015, 50 pp. 50 - 54 en
dc.identifier.issn 0739-7240 en
dc.identifier.uri en
dc.description.abstract Embryo transfer of large sheep breed embryos (Suffolk) into small breed ewes (Cheviot) constrains birth size, but the maternal factors influencing fetal growth restriction are unknown. We hypothesized that reciprocal embryo transfer crosses between breeds of divergent size would affect pregnancy-related development of maternal insulin resistance in midgestation, thereby influencing fetal growth. Following superovulation, embryos were surgically collected 6 d postmating and transferred to recipients on the same day. Between- and within-breed transfers were performed. Between 60 and 70 d of pregnancy overnight-fasted ewes underwent hyperinsulinemic-euglycemic clamps for assessment of insulin sensitivity. Maternal insulin sensitivity did not vary with transferred lamb breed. Overall, Cheviot ewes tended to have higher fasting glucose (P = 0.068), fasting insulin (P = 0.052), and steady-state glucose (P = 0.065) concentrations than Suffolk ewes at the stage of pregnancy studied. As expected, transferred between-breed Suffolk lambs were born lighter (P = 0.014), and transferred between-breed Cheviot lambs tended to be heavier at birth (P = 0.056) than respective lambs transferred within breed. Midgestation insulin sensitivity does not appear to be a major factor constraining growth of large breed sheep fetus transferred into smaller breed or a factor in releasing constraint in growth of a small breed fetus within a larger breed ewe. However, as embryo size is already different between transferred groups by 19 d, factors other than maternal gestational insulin resistance may determine fetal growth in this embryo transfer paradigm. en
dc.description.uri en
dc.publisher Elsevier en
dc.relation.ispartofseries Domestic Animal Endocrinology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject Animals en
dc.subject Animals, Newborn en
dc.subject Sheep en
dc.subject Insulin Resistance en
dc.subject Birth Weight en
dc.subject Body Size en
dc.subject Embryo Transfer en
dc.subject Pregnancy en
dc.subject Pregnancy, Animal en
dc.subject Female en
dc.title Maternal insulin sensitivity in midpregnancy does not determine birth weight after embryo transfer between large and small breed sheep en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.domaniend.2014.08.001 en
pubs.begin-page 50 en
pubs.volume 50 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 25254312 en en
pubs.end-page 54 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 457028 en Liggins Institute en LiFePATH en Medical and Health Sciences en School of Medicine en Paediatrics Child & Youth Hlth en
dc.identifier.eissn 1879-0054 en
pubs.record-created-at-source-date 2016-08-04 en
pubs.dimensions-id 25254312 en

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