Parenteral administration of twin-bearing ewes with L-arginine enhances the birth weight and brown fat stores in sheep

Show simple item record McCoard, S en Sales, F en Wards, N en Sciascia, Q en Oliver, Mark en Koolaard, J en van der Linden, D en 2016-08-04T01:00:42Z en 2013 en
dc.identifier.citation SpringerPlus, 2013, 2 pp. 1 - 12 en
dc.identifier.issn 2193-1801 en
dc.identifier.uri en
dc.description.abstract The objective of this study was to evaluate the effects of parenteral administration of L-arginine (Arg) to well-fed twin-bearing ewes from day (d) 100 of pregnancy to birth on fetal growth, body composition and neonatal behavior. Ewes received an i.v. bolus of either 345 μmol Arg-HCl/kg bodyweight or saline solution (control) 3 times a day. At d 140 of pregnancy, Arg-supplemented and control ewes were euthanized and fetal weight and fetal organ weight recorded, and maternal and fetal plasma concentrations of amino acids, hormones and metabolites analyzed. A subset of ewes was allowed to lamb and birth weight, body dimensions and behavior of the lambs in the first 2 hours(h) following birth recorded and blood samples collected. At d 140 of pregnancy, fetal weight internal organ weights were unaffected by treatment with the exception of brown fat stores which were increased by 16% in fetuses from Arg-supplemented ewes relative to controls (P < 0.05). At birth, there was an interaction (P = 0.06) between treatment and sex for birth weight of the lamb. The ewe lambs from Arg-supplemented ewes were 12% (P < 0.05) heavier at birth compared with controls whereas birth weight of male lambs did not differ. These results indicate that maternal Arg supplementation enhanced brown fat stores in the fetus and countered some effect of fetal growth restriction due to litter size in female lambs. Increasing birth weight of female lambs and enhancing brown fat stores of all lambs may have important implications for lamb survival and postnatal growth. en
dc.description.uri en
dc.publisher SpringerOpen en
dc.relation.ispartofseries SpringerPlus en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.rights.uri en
dc.subject Amino acids en
dc.subject Arginine en
dc.subject Birth weight en
dc.subject Fetal en
dc.subject Sheep en
dc.title Parenteral administration of twin-bearing ewes with L-arginine enhances the birth weight and brown fat stores in sheep en
dc.type Journal Article en
dc.identifier.doi 10.1186/2193-1801-2-684 en
pubs.begin-page 1 en
pubs.volume 2 en
dc.description.version VoR – Version of Record en
dc.rights.holder Copyright: The Authors en
dc.identifier.pmid 24422179 en en
pubs.end-page 12 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 424017 en Liggins Institute en LiFePATH en
dc.identifier.eissn 2193-1801 en
dc.identifier.pii 765 en
pubs.number 684 en
pubs.record-created-at-source-date 2016-08-04 en
pubs.dimensions-id 24422179 en

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