Structure of AKR1C3 with 3-phenoxybenzoic acid bound

Jackson, VJ; Yosaatmadja, Yuliana; Flanagan, Jack; Squire, Christopher

dc.contributor.author	Jackson, VJ	en
dc.contributor.author	Yosaatmadja, Yuliana	en
dc.contributor.author	Flanagan, Jack	en
dc.contributor.author	Squire, Christopher	en
dc.date.accessioned	2016-08-05T04:09:19Z	en
dc.date.issued	2012-04	en
dc.identifier.citation	Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2012, 68 (Part 4), pp. 409 - 413	en
dc.identifier.issn	1744-3091	en
dc.identifier.uri	http://hdl.handle.net/2292/29823	en
dc.description.abstract	Aldo-keto reductase 1C3 (AKR1C3) is a human enzyme that catalyzes the NADPH-dependent reduction of steroids and prostaglandins. AKR1C3 overexpression is associated with the proliferation of hormone-dependent cancers, most notably breast and prostate cancers. Nonsteroidal anti-inflammatory drugs (NSAIDs) and their analogues are well characterized inhibitors of AKR1C3. Here, the X-ray crystal structure of 3-phenoxybenzoic acid in complex with AKR1C3 is presented. This structure provides useful information for the future development of new anticancer agents by structure-guided drug design.	en
dc.description.uri	http://journals.iucr.org/f/index.html	en
dc.publisher	International Union of Crystallography	en
dc.relation.ispartofseries	Acta Crystallographica Section F: Structural Biology and Crystallization Communications	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1744-3091/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	3-Hydroxysteroid Dehydrogenases	en
dc.subject	Benzoates	en
dc.subject	Catalytic Domain	en
dc.subject	Enzyme Inhibitors	en
dc.subject	Humans	en
dc.subject	Hydroxyprostaglandin Dehydrogenases	en
dc.subject	Ligands	en
dc.subject	Models, Molecular	en
dc.subject	Protein Binding	en
dc.subject	Protein Interaction Domains and Motifs	en
dc.title	Structure of AKR1C3 with 3-phenoxybenzoic acid bound	en
dc.type	Journal Article	en
dc.identifier.doi	10.1107/S1744309112009049	en
pubs.issue	Part 4	en
pubs.begin-page	409	en
pubs.volume	68	en
dc.description.version	VoR – Version of Record	en
dc.rights.holder	Copyright: International Union of Crystallography	en
dc.identifier.pmid	22505408	en
pubs.author-url	http://journals.iucr.org/f/issues/2012/04/00/hv5211/index.html	en
pubs.end-page	413	en
pubs.publication-status	Published	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/OpenAccess	en
pubs.subtype	Article	en
pubs.elements-id	344770	en
pubs.org-id	Medical and Health Sciences	en
pubs.org-id	Medical Sciences	en
pubs.org-id	Pharmacology	en
pubs.org-id	Science	en
pubs.org-id	Biological Sciences	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
dc.identifier.eissn	1744-3091	en
dc.identifier.pii	S1744309112009049	en
pubs.record-created-at-source-date	2012-10-11	en
pubs.dimensions-id	22505408	en