dc.contributor.author |
Martin, RF |
en |
dc.contributor.author |
Broadhurst, S |
en |
dc.contributor.author |
Reum, ME |
en |
dc.contributor.author |
Squire, Christopher |
en |
dc.contributor.author |
Clark, George |
en |
dc.contributor.author |
Lobachevsky, PN |
en |
dc.contributor.author |
White, Janice |
en |
dc.contributor.author |
Clark, C |
en |
dc.contributor.author |
Sy, D |
en |
dc.contributor.author |
Spotheim-Maurizot, M |
en |
dc.contributor.author |
Kelly, DP |
en |
dc.date.accessioned |
2016-08-09T02:38:47Z |
en |
dc.date.issued |
2004-02 |
en |
dc.identifier.citation |
Cancer Research, 2004, 64 (3), pp. 1067 - 1070 |
en |
dc.identifier.issn |
0008-5472 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/29859 |
en |
dc.description.abstract |
New analogues of the minor groove binding ligand Hoechst 33342 have been investigated in an attempt to improve radioprotective activity. The synthesis, DNA binding, and in vitro radioprotective properties of methylproamine, the most potent derivative, are reported. Experiments with V79 cells have shown that methylproamine is ∼100-fold more potent than the classical aminothiol radioprotector WR1065. The crystal structures of methylproamine and proamine complexes with the dodecamer d(CGCGAATTCGCG)2 confirm that the new analogues also are minor groove binders. It is proposed that the DNA-bound methylproamine ligand acts as a reducing agent by an electron transfer mechanism, repairing transient radiation-induced oxidizing species on DNA. |
en |
dc.description.uri |
http://cancerres.aacrjournals.org/ |
en |
dc.publisher |
American Association for Cancer Research |
en |
dc.relation.ispartofseries |
Cancer Research |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0008-5472/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
In vitro studies with methylproamine: A potent new radioprotector |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1158/0008-5472.CAN-03-2423 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
1067 |
en |
pubs.volume |
64 |
en |
dc.rights.holder |
Copyright:
American Association for Cancer Research |
en |
dc.identifier.pmid |
14871839 |
en |
pubs.author-url |
http://cancerres.aacrjournals.org/content/canres/64/3/1067.full.pdf |
en |
pubs.end-page |
1070 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
6783 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1538-7445 |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
14871839 |
en |