Minor groove binding of a bis-quaternary ammonium compound: the crystal structure of SN 7167 bound to d(CGCGAATTCGCG)2

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dc.contributor.author Squire, Christopher en
dc.contributor.author Clark, George en
dc.contributor.author Denny, William en
dc.date.accessioned 2016-08-09T06:07:57Z en
dc.date.issued 1997-10 en
dc.identifier.citation Nucleic Acids Research, 1997, 25 (20), pp. 4072 - 4078 en
dc.identifier.issn 0305-1048 en
dc.identifier.uri http://hdl.handle.net/2292/29871 en
dc.description.abstract The X-ray crystal structure of the complex between the synthetic antitumour and antiviral DNA binding ligand SN 7167 and the DNA oligonucleotide d(CGCGAATTCGCG)2 has been determined to an R factor of 18.3% at 2.6 Å resolution. The ligand is located within the minor groove and covers almost 6 bp with the 1-methylpyridinium ring extending as far as the C9-G16 base pair and the 1-methylquinolinium ring lying between the G4-C21 and A5-T20 base pairs. The ligand interacts only weakly with the DNA, as evidenced by long range contacts and shallow penetration into the groove. This structure is compared with that of the complex between the parent compound SN 6999 and the alkylated DNA sequence d(CGC[e6G]AATTCGCG)2. There are significant differences between the two structures in the extent of DNA bending, ligand conformation and groove binding. en
dc.description.uri http://nar.oxfordjournals.org/ en
dc.publisher Oxford University Press (OUP) en
dc.relation.ispartofseries Nucleic Acids Research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0305-1048/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/3.0/ en
dc.title Minor groove binding of a bis-quaternary ammonium compound: the crystal structure of SN 7167 bound to d(CGCGAATTCGCG)2 en
dc.type Journal Article en
dc.identifier.doi 10.1093/nar/25.20.4072 en
pubs.issue 20 en
pubs.begin-page 4072 en
pubs.volume 25 en
dc.description.version VoR – Version of Record en
dc.rights.holder Copyright: Oxford University Press (OUP) en
dc.identifier.pmid 9321660 en
pubs.author-url http://nar.oxfordjournals.org/content/25/20/4072.full en
pubs.end-page 4078 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 9914 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Auckland Cancer Research en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1362-4962 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 9321660 en

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