Mangiferin and Cancer: Mechanisms of Action

Show simple item record Gold-Smith, Fuchsia en Fernandez, A en Bishop, Karen en 2016-08-23T04:27:19Z en 2016-07 en
dc.identifier.citation Nutrients, 2016, 8 (7), pp. 396 - 396 en
dc.identifier.issn 2072-6643 en
dc.identifier.uri en
dc.description.abstract Mangiferin, a bioactive compound derived primarily from Anacardiaceae and Gentianaceae families and found in mangoes and honeybush tea, has been extensively studied for its therapeutic properties. Mangiferin has shown promising chemotherapeutic and chemopreventative potential. This review focuses on the effect of mangiferin on: (1) inflammation, with respect to NFκB, PPARү and the immune system; (2) cell cycle, the MAPK pathway G2/M checkpoint; (3) proliferation and metastasis, and implications on β-catenin, MMPs, EMT, angiogenesis and tumour volume; (4) apoptosis, with a focus on Bax/Bcl ratios, intrinsic/extrinsic apoptotic pathways and telomerase activity; (5) oxidative stress, through Nrf2/ARE signalling, ROS elimination and catalase activity; and (6) efficacy of chemotherapeutic agents, such as oxaliplatin, etoposide and doxorubicin. In addition, the need to enhance the bioavailability and delivery of mangiferin are briefly addressed, as well as the potential for toxicity. en
dc.description.uri en
dc.publisher MDPI en
dc.relation.ispartofseries Nutrients en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.rights.uri en
dc.title Mangiferin and Cancer: Mechanisms of Action en
dc.type Journal Article en
dc.identifier.doi 10.3390/nu8070396 en
pubs.issue 7 en
pubs.begin-page 396 en
pubs.volume 8 en
dc.description.version VoR – Version of Record en
dc.rights.holder Copyright: The Authors en
dc.identifier.pmid 27367721 en en
pubs.end-page 396 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 535314 en Medical and Health Sciences en Medical Sciences en Auckland Cancer Research en
dc.identifier.eissn 2072-6643 en
pubs.record-created-at-source-date 2016-08-23 en
pubs.dimensions-id 27367721 en

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