Pregnancy after definitive treatment for Graves’ disease – Does treatment choice influence outcome?

Show simple item record Elston, Marianne en Tu'akoi, K en Meyer-Rochow, Goswin en Tamatea, Jade en Conaglen, John en 2016-08-26T06:16:10Z en 2014-08 en
dc.identifier.citation Australian and New Zealand Journal of Obstetrics and Gynaecology, 2014, 54 (4), pp. 317 - 321 en
dc.identifier.issn 0004-8666 en
dc.identifier.uri en
dc.description.abstract BACKGROUND: Women requiring thyroid hormone replacement after definitive therapy (surgery or radioiodine) for Graves' disease who later conceive require an early increase in levothyroxine dose and monitoring of thyroid hormone levels throughout pregnancy. In addition, as TSH receptor antibodies (TRAb) can cross the placenta and affect the fetus, measurement of these antibodies during pregnancy is recommended. AIM: To review the management of pregnancies following definitive treatment for Graves' disease in order to assess the rates of maternal hypothyroidism and TRAb measurement. MATERIALS AND METHODS: Retrospective chart review of women who had undergone definitive treatment for Graves' disease at a tertiary hospital and subsequently had one or more pregnancies. RESULTS: A total of 29 women were identified, each of whom had at least one pregnancy since receiving definitive treatment for Graves' disease: there were a total of 49 pregnancies (22 in the surgical group and 27 in the radioiodine group). Both groups had high rates of hypothyroidism documented during pregnancy (47 and 50%, respectively). The surgical group was more likely to be euthyroid around the time of conception. Less than half of the women were referred to an endocrinologist or had TRAb measured during pregnancy. Neonatal thyroid function was measured in one-third of live births. One case of neonatal thyrotoxicosis was identified. CONCLUSIONS: Adherence to the current American Thyroid Association guidelines is poor. Further education of both patients and clinicians is important to ensure that treatment of women during pregnancy after definitive treatment follows the currently available guidelines. en
dc.description.uri en
dc.publisher Wiley en
dc.relation.ispartofseries Australian and New Zealand Journal of Obstetrics and Gynaecology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject Graves’ disease en
dc.subject hyperthyroidism en
dc.subject hypothyroidism en
dc.subject prenatal care en
dc.subject thyroidectomy en
dc.subject Adult en
dc.subject Endocrinology en
dc.subject Female en
dc.subject Graves Disease en
dc.subject Guideline Adherence en
dc.subject Humans en
dc.subject Hypothyroidism en
dc.subject Immunoglobulins, Thyroid-Stimulating en
dc.subject Infant, Newborn en
dc.subject Iodine Radioisotopes en
dc.subject Postnatal Care en
dc.subject Pregnancy en
dc.subject Pregnancy Complications en
dc.subject Pregnancy Outcome en
dc.subject Pregnancy Rate en
dc.subject Prenatal Care en
dc.subject Referral and Consultation en
dc.subject Retrospective Studies en
dc.subject Thyroid Function Tests en
dc.subject Thyroidectomy en
dc.subject Young Adult en
dc.title Pregnancy after definitive treatment for Graves’ disease – Does treatment choice influence outcome? en
dc.type Journal Article en
dc.identifier.doi 10.1111/ajo.12196 en
pubs.issue 4 en
pubs.begin-page 317 en
pubs.volume 54 en
dc.description.version Pre-print en
dc.identifier.pmid 24576228 en en
pubs.end-page 321 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 429572 en Medical and Health Sciences en School of Medicine en Medicine Department en Surgery Department en Te Kupenga Hauora Maori en TKHM Teaching en
dc.identifier.eissn 1479-828X en
pubs.record-created-at-source-date 2016-08-26 en
pubs.dimensions-id 24576228 en

Files in this item

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace