Signaling Pathways in Melanogenesis

Show simple item record D'Mello, Stacey en Finlay, Graeme en Baguley, Bruce en Askarian Amiri, Effat en 2016-09-09T04:44:21Z en 2016-01 en
dc.identifier.citation International Journal of Molecular Sciences 17(7):Article number 1144 en
dc.identifier.issn 1422-0067 en
dc.identifier.uri en
dc.description.abstract Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones, heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in response to a complex network of interacting regulatory pathways. Melanins are pigment molecules that are endogenously synthesized by melanocytes. The light absorption of melanin in skin and hair leads to photoreceptor shielding, thermoregulation, photoprotection, camouflage and display coloring. Melanins are also powerful cation chelators and may act as free radical sinks. Melanin formation is a product of complex biochemical events that starts from amino acid tyrosine and its metabolite, dopa. The types and amounts of melanin produced by melanocytes are determined genetically and are influenced by a variety of extrinsic and intrinsic factors such as hormonal changes, inflammation, age and exposure to UV light. These stimuli affect the different pathways in melanogenesis. In this review we will discuss the regulatory mechanisms involved in melanogenesis and explain how intrinsic and extrinsic factors regulate melanin production. We will also explain the regulatory roles of different proteins involved in melanogenesis. en
dc.format.medium Electronic en
dc.language eng en
dc.publisher MDPI en
dc.relation.ispartofseries International Journal of Molecular Sciences en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.rights.uri en
dc.title Signaling Pathways in Melanogenesis en
dc.type Journal Article en
dc.identifier.doi 10.3390/ijms17071144 en
pubs.issue 7 en
pubs.volume 17 en
dc.description.version VoR - Version of Record en
dc.identifier.pmid 27428965 en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 536254 en Medical and Health Sciences en Medical Sciences en Auckland Cancer Research en Molecular Medicine en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1422-0067 en
pubs.number 1144 en
pubs.record-created-at-source-date 2016-09-09 en
pubs.dimensions-id 27428965 en

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