dc.contributor.author |
Earle, Nicola |
en |
dc.contributor.author |
Poppe, Katrina |
en |
dc.contributor.author |
Pilbrow, AP |
en |
dc.contributor.author |
Cameron, VA |
en |
dc.contributor.author |
Troughton, RW |
en |
dc.contributor.author |
Skinner, Jonathan |
en |
dc.contributor.author |
Love, Donald |
en |
dc.contributor.author |
Shelling, Andrew |
en |
dc.contributor.author |
Whalley, Gillian |
en |
dc.contributor.author |
Ellis, CJ |
en |
dc.contributor.author |
Richards, AM |
en |
dc.contributor.author |
Doughty, Robert |
en |
dc.date.accessioned |
2016-09-21T03:26:27Z |
en |
dc.date.issued |
2015-04 |
en |
dc.identifier.citation |
American Heart Journal 169(4):579-586.e3 Apr 2015 |
en |
dc.identifier.issn |
0002-8703 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/30447 |
en |
dc.description.abstract |
BACKGROUND: There is a genetic contribution to the risk of ventricular arrhythmias in survivors of acute coronary syndromes (ACS). We wished to explore the role of 33 candidate single nucleotide polymorphisms (SNPs) in prolonged repolarization and sudden death in patients surviving ACS. METHODS: A total of 2,139 patients (1680 white ethnicity) surviving an admission for ACS were enrolled in the prospective Coronary Disease Cohort Study. Extensive clinical, echocardiographic, and neurohormonal data were collected for 12 months, and clinical events were recorded for a median of 5 years. Each SNP was assessed for association with sudden cardiac death (SCD)/cardiac arrest (CA) and prolonged repolarization at 3 time-points: index admission, 1 month, and 12 months postdischarge. RESULTS: One hundred six SCD/CA events occurred during follow-up (6.3%). Three SNPs from 3 genes (rs17779747 [KCNJ2], rs876188 [C14orf64], rs3864180 [GPC5]) were significantly associated with SCD/CA in multivariable models (after correction for multiple testing); the minor allele of rs17779747 with a decreased risk (hazard ratio [HR] 0.68 per copy of the minor allele, 95% CI 0.50-0.92, P = .012), and rs876188 and rs386418 with an increased risk (HR 1.52 [95% CI 1.10-2.09, P = .011] and HR 1.34 [95% CI 1.04-1.82, P = .023], respectively). At 12 months postdischarge, rs10494366 and rs12143842 (NOS1AP) were significant predictors of prolonged repolarization (HR 1.32 [95% CI 1.04-1.67, P = .022] and HR 1.30 [95% CI 1.01-1.66, P = .038], respectively), but not at earlier time-points. CONCLUSION: Three SNPs were associated with SCD/CA. Repolarization time was associated with variation in the NOS1AP gene. This study demonstrates a possible role for SNPs in risk stratification for arrhythmic events after ACS. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
American Heart Journal |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
en |
dc.subject |
Genetic Predisposition to Disease |
en |
dc.subject |
DNA |
en |
dc.subject |
Genetic Markers |
en |
dc.subject |
Electrocardiography |
en |
dc.subject |
Risk Factors |
en |
dc.subject |
Follow-Up Studies |
en |
dc.subject |
Prospective Studies |
en |
dc.subject |
Genotype |
en |
dc.subject |
Polymorphism, Single Nucleotide |
en |
dc.subject |
Aged |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Arrhythmias, Cardiac |
en |
dc.subject |
Acute Coronary Syndrome |
en |
dc.title |
Genetic markers of repolarization and arrhythmic events after acute coronary syndromes |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.ahj.2014.11.015 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
579 |
en |
pubs.volume |
169 |
en |
dc.identifier.pmid |
25819866 |
en |
pubs.end-page |
586.e3 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
486524 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Population Health |
en |
pubs.org-id |
Epidemiology & Biostatistics |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
dc.identifier.eissn |
1097-6744 |
en |
pubs.record-created-at-source-date |
2016-09-21 |
en |
pubs.dimensions-id |
25819866 |
en |