dc.contributor.advisor |
Corballis, P |
en |
dc.contributor.author |
Rosentreter, Eric |
en |
dc.date.accessioned |
2016-09-21T23:34:03Z |
en |
dc.date.issued |
2016 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/30455 |
en |
dc.description |
Full text is available to authenticated members of The University of Auckland only. |
en |
dc.description.abstract |
Animal models of long-term potentiation are one of the most studied mechanisms of learning, however these invasive methods are not practised in humans. A novel paradigm known as ‘visual LTP’ has been suggested as a human analogue for synaptic plasticity assessment. This non-invasive method involves passive viewing of stimuli, while EEG is recorded at different time points to determine event-related potential (ERP) change. A high-frequency stimulation (8.6 Hz) protocol mimics neuronal tetanus, which brings about a stimulus specific change in the N1b component. The N1b modulation post HFS has been replicated many times, however the perceptual consequences of LTP-like change, which are intended to underlie learning, have not been as thoroughly investigated. A Bayesian adaptive psychophysics task was used to assess contrast sensitivity for the stimulated (HFS) and non-stimulated stimulus. The LTP-like N1b modulation was effectively induced for a specific stimulus, however there was also a transfer effect to the non-stimulated stimulus. The subsequent behavioural task revealed an increase in psychometric threshold for the stimulated stimulus compared to the non-stimulated. Thus the stimulus specific HFS appeared to reduce contrast sensitivity for said stimulus. Potential reasons for this result will be discussed. Keywords: Adaptive Psychophysics, Electrophysiology, Neuroplasticity, Perceptual Learning |
en |
dc.publisher |
ResearchSpace@Auckland |
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dc.relation.ispartof |
Masters Thesis - University of Auckland |
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dc.relation.isreferencedby |
UoA99264876010902091 |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
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dc.rights |
Restricted Item. Available to authenticated members of The University of Auckland. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
http://creativecommons.org/licenses/by-nc-nd/3.0/nz/ |
en |
dc.title |
In search of perceptual correlates in human visual long-term potentiation (LTP) |
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dc.type |
Thesis |
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thesis.degree.discipline |
Psychology |
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thesis.degree.grantor |
The University of Auckland |
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thesis.degree.level |
Masters |
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dc.rights.holder |
Copyright: The author |
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pubs.elements-id |
541581 |
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pubs.org-id |
Science |
en |
pubs.org-id |
Psychology |
en |
pubs.record-created-at-source-date |
2016-09-22 |
en |
dc.identifier.wikidata |
Q112926382 |
|