dc.contributor.author |
Reid, Ian |
en |
dc.contributor.author |
Sharma, S |
en |
dc.contributor.author |
Kalluru, R |
en |
dc.contributor.author |
Eagleton, C |
en |
dc.date.accessioned |
2016-10-05T22:58:32Z |
en |
dc.date.available |
2016-05-06 |
en |
dc.date.issued |
2016-09 |
en |
dc.identifier.citation |
Calcified Tissue International, 2016, 99 (3), 322 - 325 |
en |
dc.identifier.issn |
0171-967X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/30631 |
en |
dc.description.abstract |
Paget's disease is a condition involving focal overactivity of bone cells (osteoblasts and osteoclasts), which can result in significant skeletal morbidity. It is unclear in which bone cells the causative lesion resides. It is managed effectively with potent bisphosphonates, but treatment is difficult if these drugs are contraindicated. We describe a 75-year-old woman with Paget's disease involving the skull who was intolerant of bisphosphonates, so was treated with denosumab. This intervention normalized serum alkaline phosphatase for 4-8 months after each injection and led to some symptomatic improvement. Scintigraphic activity in the lesion was improved but not normalized. We conclude that reduction in RANKL activity by denosumab only partially corrects pagetic activity, indicating that the osteoclast overactivity of Paget's disease is not wholly mediated by RANKL. Denosumab has some clinical utility in Paget's disease and may become a second-line agent in those with contraindications to intravenous bisphosphonates. |
en |
dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/27193832 |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
English |
en |
dc.publisher |
Springer |
en |
dc.relation.ispartofseries |
Calcified Tissue International |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0171-967X/
http://www.springer.com/gp/open-access/authors-rights/self-archiving-policy/2124 |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Paget's disease |
en |
dc.subject |
Denosumab |
en |
dc.subject |
Alendronate |
en |
dc.title |
Treatment of Paget's Disease of Bone with Denosumab: Case Report and Literature Review |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s00223-016-0150-6 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
322 |
en |
pubs.volume |
99 |
en |
dc.description.version |
VoR - Version of Record |
en |
dc.identifier.pmid |
27193832 |
en |
pubs.author-url |
http://link.springer.com/article/10.1007/s00223-016-0150-6 |
en |
pubs.end-page |
325 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
529015 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1432-0827 |
en |
pubs.record-created-at-source-date |
2016-10-06 |
en |
pubs.online-publication-date |
2016-05-18 |
en |
pubs.dimensions-id |
27193832 |
en |