Treatment of Paget's Disease of Bone

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Show simple item record Reid, Ian en
dc.contributor.editor Reddy, SV en 2016-10-07T01:20:48Z en 2016 en
dc.identifier.citation In S. V. Reddy (Ed.), 2016, Advances in Pathobiology and Management of Paget's Disease of Bone (pp. 119-136). Elsevier / Academic Press, London. en
dc.identifier.isbn 012809690X en
dc.identifier.isbn 9780128096901 en
dc.identifier.uri en
dc.description.abstract Paget's disease involves overactivity of both osteoblasts and osteoclasts within affected bone tissue. It is unclear in which cells the causative lesion resides, but therapies have generally been antiosteoclastic (antiresorptive) because these are the only pharmaceuticals that have been available. There is tight coupling between osteoblasts and osteoclasts, so antiresorptive therapies lead to decreases in osteoclast activity within days, followed by similar declines in osteoblast activity after a period of 2-3 months. The most commonly used test for monitoring disease activity is serum total alkaline phosphatase, which is a measure of osteoblast activity, though serum procollagen type I N-terminal propeptide is more bone-specific. The treatment of Paget's disease is now virtually always with a potent bisphosphonate, typically intravenous zoledronate since this has the highest rates of biochemical response and the greatest response longevity. en
dc.publisher Elsevier / Academic Press en
dc.relation.ispartof Advances in Pathobiology and Management of Paget's Disease of Bone en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Treatment of Paget's Disease of Bone en
dc.type Book Item en
dc.identifier.doi 10.1016/B978-0-12-805083-5.00009-9 en
pubs.begin-page 119 en en
pubs.end-page 136 en London en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.elements-id 539233 en Medical and Health Sciences en School of Medicine en Medicine Department en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
pubs.number 9 en
pubs.record-created-at-source-date 2016-10-07 en

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