A computational model of the topographic distribution of ventilation in healthy human lungs

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dc.contributor.author Swan, AJ en
dc.contributor.author Clark, Alys en
dc.contributor.author Tawhai, Merryn en
dc.date.accessioned 2016-10-28T04:30:49Z en
dc.date.available 2012-01-27 en
dc.date.issued 2012-05-07 en
dc.identifier.citation Journal of Theoretical Biology, 2016, 300, 222 - 231 en
dc.identifier.issn 0022-5193 en
dc.identifier.uri http://hdl.handle.net/2292/30886 en
dc.description.abstract The topographic distribution of ventilation in the lungs is determined by the interaction of several factors, including lung shape, airway tree geometry, posture, and tissue deformation. Inter-species differences in lung structure-function and technical difficulty in obtaining high resolution imaging of the upright human lung means that it is not straightforward to experimentally determine the contribution of each of these factors to ventilation distribution. We present a mathematical model for predicting the topological distribution of inhaled air in the upright healthy human lung, based on anatomically structured model geometries and biophysical equations for model function. Gravitational deformation of the lung tissue is predicted using a continuum model. Airflow is simulated in anatomically based conducting airways coupled to geometrically simplified terminal acinar units with varying volume-dependent compliances. The predicted ventilation distribution is hence governed by local tissue density and elastic recoil pressure, airway resistance and acinar compliance. Results suggest that there is significant spatial variation in intrinsic tissue properties in the lungs. The model confirms experimental evidence that in the healthy lungs tissue compliance has a far greater effect than airway resistance on the spatial distribution of ventilation, and hence a realistic description of tissue deformation is essential in models of ventilation. en
dc.description.uri https://www.ncbi.nlm.nih.gov/pubmed/22326472 en
dc.language English en
dc.publisher Elsevier en
dc.relation.ispartofseries Journal of Theoretical Biology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0022-5193/ https://www.elsevier.com/about/company-information/policies/sharing en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title A computational model of the topographic distribution of ventilation in healthy human lungs en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jtbi.2012.01.042 en
pubs.begin-page 222 en
pubs.volume 300 en
dc.description.version AO - Author's Original en
dc.identifier.pmid 22326472 en
pubs.author-url http://www.sciencedirect.com/science/article/pii/S0022519312000628 en
pubs.end-page 231 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 287629 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
dc.identifier.eissn 1095-8541 en
pubs.record-created-at-source-date 2012-02-07 en
pubs.online-publication-date 2012-02-05 en
pubs.dimensions-id 22326472 en

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