dc.contributor.advisor |
Dr. S.J. M. Skinner |
en |
dc.contributor.advisor |
Professor R.C. Cambie |
en |
dc.contributor.author |
Couch, Ronald Alexander Fyfe |
en |
dc.date.accessioned |
2008-10-16T23:16:29Z |
en |
dc.date.available |
2008-10-16T23:16:29Z |
en |
dc.date.issued |
1980 |
en |
dc.identifier.citation |
Thesis (PhD--Surgery)--University of Auckland, 1980. |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/3089 |
en |
dc.description.abstract |
Human mammary tissue was incubated in vitro with [7-3H]
dehydroepiandrosterone sulphate (DHA-sulphate) and in agreement with
other investigators this steroid conjugate was metabolized to DHA
and other steroid products. Sulphatase activity was greater in
the malignant than the non-malignant tissues and was found to be a
function of the tissue cellularity. One of the major products, a "polar steroid" necessitated identification.
The "polar steroid" was identified principally as 7a-hydroxy DHA
by chemical modification techniques and co-crystallization of the
purified steroid metabolite with carrier 7a-hydroxy DHA. This
carrier required synthesis and characterization. |
en |
dc.format |
Scanned from print thesis |
en |
dc.language.iso |
en |
en |
dc.publisher |
ResearchSpace@Auckland |
en |
dc.relation.ispartof |
PhD Thesis - University of Auckland |
en |
dc.relation.isreferencedby |
UoA777075 |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
The metabolism of steroids by human mammary tissues |
en |
dc.type |
Thesis |
en |
thesis.degree.discipline |
Medical and Health Sciences |
en |
thesis.degree.grantor |
The University of Auckland |
en |
thesis.degree.level |
Doctoral |
en |
thesis.degree.name |
PhD |
en |
dc.subject.marsden |
Fields of Research::320000 Medical and Health Sciences::321000 Clinical Sciences::321029 Surgery |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.local.anzsrc |
11 - Medical and Health Sciences |
en |
pubs.org-id |
Faculty of Medical & Hlth Sci |
en |
dc.identifier.wikidata |
Q112846486 |
|