dc.contributor.author |
Ayyavoo, Ahila |
en |
dc.contributor.author |
Behrensdorf Derraik, Jose |
en |
dc.contributor.author |
Hofman, Paul |
en |
dc.contributor.author |
Biggs, Janene |
en |
dc.contributor.author |
Bloomfield, Francis |
en |
dc.contributor.author |
Cormack, Barbara |
en |
dc.contributor.author |
Stone, Peter |
en |
dc.contributor.author |
Cutfield, Wayne |
en |
dc.coverage.spatial |
United States |
en |
dc.date.accessioned |
2016-11-20T22:12:39Z |
en |
dc.date.available |
2013-06-03 |
en |
dc.date.issued |
2013-08 |
en |
dc.identifier.citation |
Journal of Clinical Endocrinology and Metabolism, Aug 2013, 98 (8), 3263 - 3268 |
en |
dc.identifier.issn |
0021-972X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/31100 |
en |
dc.description.abstract |
BACKGROUND: Hyperemesis gravidarum alters maternal (and possibly fetal) nutrition throughout pregnancy, but there are no data on long-term effects on offspring metabolism. Thus, we aimed to assess whether severe hyperemesis gravidarum (SHG) affects glucose homeostasis and body composition in the offspring in childhood. METHODS: Healthy prepubertal children (aged 4-11 years) born at term were studied: offspring of mothers who were admitted to hospital with SHG (n = 36) and offspring of mothers from control pregnancies (n = 42). Primary outcome was insulin sensitivity measured using iv glucose tolerance tests and Bergman's minimal model. Other assessments included lipid and hormonal profiles and body composition using whole-body dual-energy x-ray absorptiometry. RESULTS: Insulin sensitivity in SHG children was 20% lower than in controls (8.49 vs 10.60 × 10(-4)·min(-1)·(mU/L); P = .014). SHG children also had higher fasting insulin (6.88 vs 5.04 mIU/L; P = .024) and lower IGF binding protein 1 (11.8 vs 19.0 ng/mL; P = .004) concentrations than controls. Baseline cortisol concentrations were 22% higher in SHG offspring (256 vs 210 nmol/L; P = .021). Children in both groups were anthropometrically similar. CONCLUSION: Children born to mothers who experienced SHG have lower insulin sensitivity, which may increase their long-term risk of developing diabetes mellitus. Follow-up of SHG offspring is essential to determine later risk of metabolic disease. |
en |
dc.description.uri |
http://www.ncbi.nlm.nih.gov/pubmed/23750032 |
en |
dc.language |
English |
en |
dc.publisher |
Endocrine Society |
en |
dc.relation.ispartofseries |
Journal of Clinical Endocrinology and Metabolism |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0021-972X/
http://press.endocrine.org/page/authors |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Body Composition |
en |
dc.subject |
Child |
en |
dc.subject |
Child, Preschool |
en |
dc.subject |
Diabetes Mellitus, Type 2 |
en |
dc.subject |
Female |
en |
dc.subject |
Glucose |
en |
dc.subject |
Homeostasis |
en |
dc.subject |
Humans |
en |
dc.subject |
Hydrocortisone |
en |
dc.subject |
Hyperemesis Gravidarum |
en |
dc.subject |
Insulin Resistance |
en |
dc.subject |
Male |
en |
dc.subject |
Pregnancy |
en |
dc.title |
Severe hyperemesis gravidarum is associated with reduced insulin sensitivity in the offspring in childhood |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1210/jc.2013-2043 |
en |
pubs.issue |
8 |
en |
pubs.begin-page |
3263 |
en |
pubs.volume |
98 |
en |
dc.description.version |
VoR - Version of Record |
en |
dc.identifier.pmid |
23750032 |
en |
pubs.author-url |
http://press.endocrine.org/doi/full/10.1210/jc.2013-2043 |
en |
pubs.end-page |
3268 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
380646 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
LiFePATH |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
pubs.org-id |
Paediatrics Child & Youth Hlth |
en |
dc.identifier.eissn |
1945-7197 |
en |
dc.identifier.pii |
jc.2013-2043 |
en |
pubs.record-created-at-source-date |
2016-11-21 |
en |
pubs.online-publication-date |
2013-06-07 |
en |
pubs.dimensions-id |
23750032 |
en |