Dynamic Blood Flow and Wall Shear Stress in Pulmonary Hypertensive Disease

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dc.contributor.author Postles, A en
dc.contributor.author Clark, Alys en
dc.contributor.author Tawhai, Merryn en
dc.coverage.spatial Chicago, United States en
dc.date.accessioned 2016-11-23T03:34:50Z en
dc.date.issued 2014-08 en
dc.identifier.isbn 978-1-4244-7929-0 en
dc.identifier.issn 1557-170X en
dc.identifier.uri http://hdl.handle.net/2292/31125 en
dc.description.abstract This study provides new model of pulsatile flow in the pulmonary circulation in health and pulmonary hypertensive disease. Structural vascular remodeling typical of pulmonary hypertensive disease was implemented in the model by progressively altering the mechanical properties of the arterial geometry and progressively increasing the inlet pulse pressure (PP). The transmission of PP throughout the tree was shown to increase in advanced stages of disease, creating the potential for a `vicious-cycle' of damage to vasculature. Wall shear stress (WSS) was shown to be highest in the terminal arteries of the model and increased significantly with disease. A further trend observed in WSS results was that high WSS values began to `climb' the arterial tree towards the proximal vessels as disease progressed. This suggests a link between WSS and distal remodeling in pulmonary hypertensive disease, which initiates in the small muscular arteries and arterioles and spreads into larger arteries as the disease progresses. en
dc.description.uri https://embs.papercept.net/conferences/scripts/rtf/EMBC14_ContentListWeb_3.html#fd07_01 en
dc.publisher IEEE en
dc.relation.ispartof 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society en
dc.relation.ispartofseries Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://ieeexplore.ieee.org/document/6944914/?arnumber=6944914 en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Dynamic Blood Flow and Wall Shear Stress in Pulmonary Hypertensive Disease en
dc.type Conference Item en
dc.identifier.doi 10.1109/EMBC.2014.6944914 en
dc.rights.holder Copyright: IEEE en
dc.identifier.pmid 25571282 en
pubs.author-url http://ieeexplore.ieee.org/document/6944914/?arnumber=6944914 en
pubs.finish-date 2014-08-30 en
pubs.publication-status Published en
pubs.start-date 2014-08-26 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Conference Paper en
pubs.elements-id 505559 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.record-created-at-source-date 2014-12-04 en
pubs.dimensions-id 25571282 en


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