Effect of Vitamin D Supplementation on Pain: A Systematic Review and Meta-analysis

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dc.contributor.author Wu, Zhenqiang en
dc.contributor.author Malihi, Zarintaj en
dc.contributor.author Stewart, Alistair en
dc.contributor.author Lawes, CMM en
dc.contributor.author Scragg, Robert en
dc.date.accessioned 2016-11-23T23:00:10Z en
dc.date.issued 2016-09 en
dc.identifier.citation Pain Physician, 2016, 19(7), pp. 415-427 en
dc.identifier.issn 1533-3159 en
dc.identifier.uri http://hdl.handle.net/2292/31131 en
dc.description.abstract BACKGROUND: There is conflicting evidence from previous qualitative reviews on the effect of vitamin D supplementation on pain. OBJECTIVE: To determine with quantitative methods if vitamin D supplementation lowers pain levels. STUDY DESIGN: Quantitative meta-analysis of published randomized controlled trials (RCTs). SETTING: This meta-analysis examined all studies involving the effect of vitamin D supplementation on pain score. METHOD: Electronic sources (Medline, Embase, Cochrane Central Register of Controlled Trials, clinical trials website, and Google scholar) were systematically searched for RCTs of vitamin D supplementation and pain from inception of each database to October 2015. RESULTS: Nineteen RCTs with 3,436 participants (1,780 on vitamin D supplementation and 1,656 on placebo) were included in the meta-analysis. For the primary outcome (mean change in pain score from baseline to final follow-up), 8 trials with 1,222 participants on vitamin D and 1,235 on placebo reported a significantly greater mean decrease in pain score for the vitamin D group compared to placebo (mean difference -0.57, 95% CI: -1.00 to -0.15, P = 0.007). The effect from vitamin D was greater in patients recruited with pre-existing pain (P-value for interaction = 0.03). Fourteen studies (1,548 on vitamin D, 1,430 on placebo) reported the mean pain score at final follow-up outcome, and no statistical difference was observed (mean difference -0.06, 95%CI: -0.44 to 0.33, P = 0.78). In 4 studies which reported pain improvement (209 on vitamin D, 146 on placebo), the effect size although not significant, shows participants in the vitamin D supplementation group were more likely to report pain improvement compared with the placebo group (relative risk 1.38, 95%CI: 0.93 to 2.05, P = 0.11). LIMITATIONS: Only a few studies reported the mean score change from baseline to final follow-up, and we do not have enough data to determine any modifying effect of baseline vitamin D status and different doses of vitamin D supplementation on pain. CONCLUSION: A significantly greater mean decrease in pain score (primary outcome) was observed with vitamin D supplementation compared with placebo in people with chronic pain. These results suggest that vitamin D supplementation could have a role in the management of chronic pain. KEY WORDS: Meta-analysis, pain, randomized controlled trials, vitamin D supplementation. en
dc.description.uri http://www.painphysicianjournal.com/ en
dc.publisher American Society of Interventional Pain Physicians en
dc.relation.ispartofseries Pain Physician en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1533-3159/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Effect of Vitamin D Supplementation on Pain: A Systematic Review and Meta-analysis en
dc.type Journal Article en
pubs.issue 7 en
pubs.begin-page 415 en
pubs.volume 19 en
dc.rights.holder Copyright: American Society of Interventional Pain Physicians en
dc.identifier.pmid 27676659 en
pubs.author-url http://www.painphysicianjournal.com/current/abstracts?article=MzAwNA== en
pubs.end-page 427 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.elements-id 542095 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Population Health en
pubs.org-id Social & Community Health en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
dc.identifier.eissn 2150-1149 en
pubs.record-created-at-source-date 2016-11-24 en
pubs.dimensions-id 27676659 en


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