dc.contributor.author |
Tran, Kenneth |
en |
dc.contributor.author |
Han, June |
en |
dc.contributor.author |
Taberner, Andrew |
en |
dc.contributor.author |
Barrett, Carolyn |
en |
dc.contributor.author |
Crampin, EJ |
en |
dc.contributor.author |
Loiselle, Denis |
en |
dc.date.accessioned |
2016-11-28T21:42:05Z |
en |
dc.date.issued |
2016-09 |
en |
dc.identifier.citation |
American Journal of Physiology - Heart and Circulatory Physiology 311(3):H563-H571 Sep 2016 |
en |
dc.identifier.issn |
0363-6135 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/31168 |
en |
dc.description.abstract |
Salt-induced hypertension leads to development of left ventricular hypertrophy in the Dahl salt-sensitive (Dahl/SS) rat. Before progression to left ventricular failure, the heart initially undergoes a compensated hypertrophic response. We hypothesized that changes in myocardial energetics may be an early indicator of transition to failure. Dahl/SS rats and their salt-resistant consomic controls (SS-13BN) were placed on either a low- or high-salt diet to generate four cohorts: Dahl-SS rats on a low- (Dahl-LS) or high-salt diet (Dahl-HS), and SS-13BN rats on a low- (SSBN-LS) or high-salt diet (SSBN-HS). We isolated left ventricular trabeculae and characterized their mechanoenergetic performance. Our results show, at most, modest effects of salt-induced compensated hypertrophy on myocardial energetics. We found that the Dahl-HS cohort had a higher work-loop heat of activation (estimated from the intercept of the heat vs. relative afterload relationship generated from work-loop contractions) relative to the SSBN-HS cohort and a higher economy of contraction (inverse of the slope of the heat vs. active stress relation) relative to the Dahl-LS cohort. The maximum extent of shortening and maximum shortening velocity of the Dahl/SS groups were higher than those of the SS-13BN groups. Despite these differences, no significant effect of salt-induced hypertension was observed for either peak work output or peak mechanical efficiency during compensated hypertrophy. |
en |
dc.publisher |
American Physiological Society |
en |
dc.relation.ispartofseries |
American Journal of Physiology - Heart and Circulatory Physiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0363-6135/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Myocardial energetics is not compromised during compensated hypertrophy in the Dahl salt-sensitive rat model of hypertension |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1152/ajpheart.00396.2016 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
H563 |
en |
pubs.volume |
311 |
en |
dc.description.version |
AM - Accepted Manuscript |
en |
dc.identifier.pmid |
27402668 |
en |
pubs.end-page |
H571 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
535232 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
dc.identifier.eissn |
1522-1539 |
en |
pubs.record-created-at-source-date |
2016-07-08 |
en |
pubs.dimensions-id |
27402668 |
en |