Interleukin-6 is associated with chronic hyperglycemia and insulin resistance in patients after acute pancreatitis

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dc.contributor.author Gillies, Nicola en
dc.contributor.author Pendharkar, Sayali en
dc.contributor.author Asrani, Varsha en
dc.contributor.author Mathew, J en
dc.contributor.author Windsor, John en
dc.contributor.author Petrov, Maxim en
dc.date.accessioned 2016-12-08T02:55:12Z en
dc.date.issued 2016-09 en
dc.identifier.citation Pancreatology 16(5):748-755 Sep 2016 en
dc.identifier.issn 1424-3903 en
dc.identifier.uri http://hdl.handle.net/2292/31272 en
dc.description.abstract Diabetes is a pervasive disease, with a mounting prevalence and burden on health care systems. Under this collective term of diabetes falls diabetes after diseases of the exocrine pancreas, a condition which was previously under-recognised and often mislabeled as type 2 diabetes mellitus and is now increasingly acknowledged as a stand-alone entity. However, there is a paucity of clinical studies investigating the underlying pathophysiology of diabetes after acute pancreatitis, the most frequent disease of the pancreas. This study aimed to investigate the role of adipocytokines in glucose metabolism after acute pancreatitis.This was a cross-sectional follow-up study of a patient cohort diagnosed with acute pancreatitis. Fasting venous blood samples were collected to analyse markers of glucose metabolism (fasting blood glucose, haemoglobin A1c, homeostasis model assessment (HOMA-IR) as a measure of insulin resistance) and adypocytokines (adiponectin, interleukin-6, leptin, monocyte chemoattractant protein-1, retinol binding protein-4, resistin, and tumor necrosis factor-α). Participants were categorized into two groups: normoglycemia after acute pancreatitis and chronic hyperglycemia after acute pancreatitis (CHAP). Binary logistic regression and linear regression analyses were used to investigate the association between each of the adipocytokines and markers of glucose metabolism. Potential confounders were adjusted for in multivariate analyses.A total of 83 patients with acute pancreatitis were included, of whom 19 developed CHAP. Interleukin-6 was significantly associated with CHAP in both unadjusted and adjusted models (p = 0.030 and p = 0.018, respectively). Further, it was also significantly associated with HOMA-IR in both unadjusted and adjusted models (p = 0.029 and p = 0.037, respectively). Other adipocytokines were not significantly associated with markers of glucose metabolism.Interleukin-6 appears to be implicated in the development of chronic hyperglycemia and insulin resistance in patients after acute pancreatitis. It may become a potential target in the prevention and early treatment of diabetes after diseases of the exocrine pancreas. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.publisher Elsevier en
dc.relation.ispartofseries Pancreatology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Interleukin-6 is associated with chronic hyperglycemia and insulin resistance in patients after acute pancreatitis en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.pan.2016.06.661 en
pubs.issue 5 en
pubs.begin-page 748 en
pubs.volume 16 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 27401909 en
pubs.end-page 755 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 535763 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Nutrition en
pubs.org-id School of Medicine en
pubs.org-id Surgery Department en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1424-3911 en
pubs.record-created-at-source-date 2016-12-08 en
pubs.online-publication-date 2016-07-02 en
pubs.dimensions-id 27401909 en


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