Synthesis of Psychrophilin E

Ngen, STY; Kaur, Harveen; Hume, Paul; Furkert, Daniel; Brimble, Margaret

dc.contributor.author	Ngen, STY	en
dc.contributor.author	Kaur, Harveen	en
dc.contributor.author	Hume, Paul	en
dc.contributor.author	Furkert, Daniel	en
dc.contributor.author	Brimble, Margaret	en
dc.date.accessioned	2016-12-13T04:21:17Z	en
dc.date.issued	2016	en
dc.identifier.citation	Journal of Organic Chemistry, 2016, 81(17), pp. 7635 - 7643	en
dc.identifier.issn	0022-3263	en
dc.identifier.uri	http://hdl.handle.net/2292/31357	en
dc.description.abstract	The first total synthesis of psychrophilin E, a potent antiproliferative cyclic tripeptide isolated from Aspergillus versicolor ZLN-60, is reported herein. Key features of the synthesis include the installation of an amide bond between the indole-nitrogen of tryptophan and an anthranilic acid residue, and a high yielding macrolactamization of the linear tripeptide to the desired macrocycle.	en
dc.description.uri	http://pubs.acs.org/journal/joceah/about.html	en
dc.publisher	American Chemical Society	en
dc.relation.ispartofseries	Journal of Organic Chemistry	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0022-3263/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.title	Synthesis of Psychrophilin E	en
dc.type	Journal Article	en
dc.identifier.doi	10.1021/acs.joc.6b01369	en
pubs.issue	17	en
pubs.begin-page	7635	en
pubs.volume	81	en
dc.rights.holder	Copyright: American Chemical Society	en
dc.identifier.pmid	27442351	en
pubs.author-url	http://pubs.acs.org/doi/pdfplus/10.1021/acs.joc.6b01369	en
pubs.end-page	7643	en
pubs.publication-status	Published	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	544245	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
dc.identifier.eissn	1520-6904	en
pubs.record-created-at-source-date	2016-10-31	en
pubs.online-publication-date	2016-07-21	en
pubs.dimensions-id	27442351	en