Macromolecular Markers in Normal Human Retina and Applications to Human Retinal Disease

Show simple item record de Souza, CF en Nivison-Smith, L en Christie, David en Polkinghorne, P en McGhee, Charles en Kalloniatis, M en Acosta Etchebarne, Monica en 2017-01-11T20:37:32Z en 2016-01-04 en 2016-09 en
dc.identifier.citation Experimental Eye Research, September 2016, 150, 135 - 148 en
dc.identifier.issn 0014-4835 en
dc.identifier.uri en
dc.description.abstract Macromolecular cell markers are essential for the classification and characterization of the highly complex and cellularly diverse vertebrate retina. Although a plethora of markers are described in the current literature, the immunoreactivity of these markers in normal human tissue has not been fully determined. This is problematic as they are quintessential to the characterization of morphological changes associated with human retinal disease. This review provides an overview of the macromolecular markers currently available to assess human retinal cell types. We draw on immunohistochemical studies conducted in our laboratories to describe marker immunoreactivity in human retina alongside comparative descriptions in non-human tissues. Considering the growing number of eye banks services offering healthy and diseased human retinal tissue, this review provides a point of reference for future human retina studies and highlights key species specific disease applications of some macromolecular markers. en
dc.description.uri en
dc.format.medium Print-Electronic en
dc.language English en
dc.publisher Elsevier en
dc.relation.ispartofseries Experimental Eye Research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Macromolecular Markers in Normal Human Retina and Applications to Human Retinal Disease en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.exer.2016.01.002 en
pubs.begin-page 135 en
pubs.volume 150 en
dc.description.version VoR - Version of Record en
dc.identifier.pmid 26769220 en en
pubs.end-page 148 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 517587 en Medical and Health Sciences en Optometry and Vision Science en School of Medicine en Ophthalmology Department en
dc.identifier.eissn 1096-0007 en
pubs.record-created-at-source-date 2017-01-12 en
pubs.dimensions-id 26769220 en

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