dc.contributor.author |
Selak, Vanessa |
en |
dc.contributor.author |
Bullen, Christopher |
en |
dc.contributor.author |
Stepien, S |
en |
dc.contributor.author |
Arroll, Bruce |
en |
dc.contributor.author |
Bots, M |
en |
dc.contributor.author |
Bramley, D |
en |
dc.contributor.author |
Cass, A |
en |
dc.contributor.author |
Grobbee, D |
en |
dc.contributor.author |
Hillis, GS |
en |
dc.contributor.author |
Molanus, B |
en |
dc.contributor.author |
Neal, B |
en |
dc.contributor.author |
Patel, A |
en |
dc.contributor.author |
Rafter, N |
en |
dc.contributor.author |
Rodgers, A |
en |
dc.contributor.author |
Thom, S |
en |
dc.contributor.author |
Tonkin, A |
en |
dc.contributor.author |
Usherwood, T |
en |
dc.contributor.author |
Wadham, A |
en |
dc.contributor.author |
Webster, R |
en |
dc.date.accessioned |
2017-02-08T02:26:14Z |
en |
dc.date.issued |
2016-09 |
en |
dc.identifier.citation |
European Journal of Preventive Cardiology 23(13):1393-1400 Sep 2016 |
en |
dc.identifier.issn |
2047-4873 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/31771 |
en |
dc.description.abstract |
The aim of this study was to investigate whether polypill-based care for the prevention of cardiovascular disease (CVD) is associated with a change in lifestyle risk factors when compared with usual care, among patients with CVD or high calculated cardiovascular risk.We conducted an individual participant data meta-analysis of three trials including patients from Australia, England, India, Ireland, the Netherlands and New Zealand that compared a strategy using a polypill containing aspirin, statin and antihypertensive therapy with usual care in patients with a prior CVD event or who were at high risk of their first event. Analyses investigated any differential effect on anthropometric measures and self-reported lifestyle behaviours.Among 3140 patients (75% male, mean age 62 years and 76% with a prior CVD event) there was no difference in lifestyle risk factors in those randomised to polypill-based care compared with usual care over a median of 15 months, either across all participants combined, or in a range of subgroups. Furthermore, narrow confidence intervals (CIs) excluded any major effect; for example differences between the groups in body mass index was -0.1 (95% CI -0.2 to 0.1) kg/m(2), in weekly duration of moderate intensity physical activity was -2 (-26 to 23) minutes and the proportion of smokers was 16% vs 17% (RR 0.98, 0.84 to 1.15) at the end of trial.This analysis allays concern that polypill-based care may lead to neglect of lifestyle risk factors, at least among high-risk patients. Maximally effective preventive approaches should address lifestyle factors alongside pharmaceutical interventions, as recommended by major international guidelines. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
SAGE Publications Ltd |
en |
dc.relation.ispartofseries |
European Journal of Preventive Cardiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Do polypills lead to neglect of lifestyle risk factors? Findings from an individual participant data meta-analysis among 3140 patients at high risk of cardiovascular disease |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1177/2047487316638216 |
en |
pubs.issue |
13 |
en |
pubs.begin-page |
1393 |
en |
pubs.volume |
23 |
en |
dc.identifier.pmid |
26945024 |
en |
pubs.end-page |
1400 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
524590 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Population Health |
en |
pubs.org-id |
Epidemiology & Biostatistics |
en |
pubs.org-id |
Gen.Practice& Primary Hlthcare |
en |
pubs.org-id |
Pacific Health |
en |
dc.identifier.eissn |
2047-4881 |
en |
pubs.record-created-at-source-date |
2017-02-08 |
en |
pubs.online-publication-date |
2016-03-04 |
en |
pubs.dimensions-id |
26945024 |
en |