Biochemical insights into Primary hyperoxaluria type III

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dc.contributor.author Loomes, Kerry en
dc.coverage.spatial London en
dc.date.accessioned 2017-02-08T23:30:02Z en
dc.date.issued 2016-09-21 en
dc.identifier.citation Rare Metabolic Disorders: Detection, Research, Management and Treatment, 21 September 2016, London en
dc.identifier.uri http://hdl.handle.net/2292/31779 en
dc.description.abstract Primary hyperoxaluria 3 (PH3) is a rare, autosomal-recessive inherited disorder characterized by increased oxalate production. It is caused by mutations in the HOGA1 gene encoding the enzyme 4-hydroxy-2-oxoglutarate aldolase (HOGA). Although these clinical mutations lead to the loss of enzymatic function it is still not clear what the metabolic fates of these mutant are within the cell. In this presentation I will describe our research showing the mechanisms by which the cell processes these aberrant HOGA forms as well as findings on another associated activity of HOGA that participates in the Kreb’s cycle. en
dc.relation.ispartof Rare Metabolic Disorders: Detection, Research, Management and Treatment en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Biochemical insights into Primary hyperoxaluria type III en
dc.type Presentation en
pubs.author-url http://www.globaleventslist.elsevier.com/events/2016/09/rare-metabolic-disorders-detection-research-management-and-treatment/ en
pubs.finish-date 2016-09-22 en
pubs.start-date 2016-09-20 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Conference Oral Presentation en
pubs.elements-id 547252 en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2016-11-28 en


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