Donor Hepatic Steatosis and Outcome After Liver Transplantation: a Systematic Review.

Show simple item record Chu, Jen en Dare, AJ en Phillips, Anthony en Bartlett, Adam en
dc.coverage.spatial United States en 2017-02-09T04:22:48Z en 2015-04-15 en 2015-09 en
dc.identifier.citation Journal of Gastrointestinal Surgery, September 2015, 19 (9), 1713 - 1724 en
dc.identifier.issn 1091-255X en
dc.identifier.uri en
dc.description.abstract BACKGROUND: There is increasing need to expand availability of donor liver grafts, including steatotic livers. Steatotic liver is associated with poor outcome post-transplantation but with conflicting results in the literature. The aim of this systematic review was to evaluate the impact of steatotic livers on liver transplantation outcomes. METHODS: An electronic search of OVID Medline and Embase databases was performed to identify clinical studies that reported outcomes of steatotic livers in liver transplantation. Data were extracted, and basic descriptive statistics were used to summarise data pooled from individual clinical studies. RESULTS: Ninety-two articles were identified, of which 34 met the inclusion criteria, and stratified analysis were performed. There was a lack of standardised definition of primary non-function or impaired primary function amongst the studies and description of type of steatosis. Severely (>60%) steatotic grafts are associated with increased risk of poor graft function, whilst moderate-severe (>30%) steatotic grafts are associated with decreased graft survival. CONCLUSIONS: Available evidence showed increased risk of poor graft outcome in moderate-severe steatotic livers. A large prospective multi-centred trial will be required to identify the true risks of steatotic livers. Consistent definition of primary non-function/impaired primary function and description of type of steatosis is also required. en
dc.description.uri en
dc.language English en
dc.publisher Springer / The Society for Surgery of the Alimentary Tract en
dc.relation.ispartofseries Journal of Gastrointestinal Surgery en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject Allografts en
dc.subject Delayed Graft Function en
dc.subject Fatty Liver en
dc.subject Graft Survival en
dc.subject Humans en
dc.subject Liver Transplantation en
dc.title Donor Hepatic Steatosis and Outcome After Liver Transplantation: a Systematic Review. en
dc.type Journal Article en
dc.identifier.doi 10.1007/s11605-015-2832-1 en
pubs.issue 9 en
pubs.begin-page 1713 en
pubs.volume 19 en
dc.description.version VoR - Version of Record en
dc.identifier.pmid 25917535 en en
pubs.end-page 1724 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 486953 en Medical and Health Sciences en School of Medicine en Surgery Department en Science en Biological Sciences en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1873-4626 en
pubs.record-created-at-source-date 2017-02-09 en 2015-04-28 en
pubs.dimensions-id 25917535 en

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