dc.contributor.author |
Milan, Amber |
en |
dc.contributor.author |
Nuora, A |
en |
dc.contributor.author |
Pundir, Shikha |
en |
dc.contributor.author |
Pileggi, CA |
en |
dc.contributor.author |
Markworth, JF |
en |
dc.contributor.author |
Linderborg, KM |
en |
dc.contributor.author |
Cameron-Smith, David |
en |
dc.date.accessioned |
2017-02-13T02:46:26Z |
en |
dc.date.available |
2015-11-16 |
en |
dc.date.issued |
2016-03-14 |
en |
dc.identifier.citation |
British Journal of Nutrition, 14 March 2016, 115 (5), 791 - 799 |
en |
dc.identifier.issn |
0007-1145 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/31813 |
en |
dc.description.abstract |
Ageing is associated with a prolonged and exaggerated postprandial lipaemia. This study aimed to examine the contribution of alterations in chylomicron synthesis, size and lipid composition to increased lipaemia. Healthy older (60-75 years; n 15) and younger (20-25 years; n 15) subjects consumed a high-fat breakfast. Chylomicron dynamics and fatty acid composition were analysed for 5 h in the postprandial state. Plasma TAG levels were elevated following the meal in the older subjects, relative to younger subjects (P<0·01). For older subjects compared with younger subjects, circulating chylomicron particle size was smaller (P<0·05), with greater apoB content (P<0·05) at all postprandial time points. However, total chylomicron TAG concentration between the groups was unaltered post-meal. Compared with younger subjects, the older subjects exhibited a greater proportion of oleic acid in the TAG and phospholipid (PL) fraction (P<0·05), plus lower proportions of linoleic acid in the TAG fraction of the chylomicrons (P<0·01). Thus, following the ingestion of a high-fat meal, older individuals demonstrate both smaller, more numerous chylomicrons, with a greater total MUFA and lower PUFA contents. These data suggest that the increased postprandial lipaemia of ageing cannot be attributed to increased chylomicron TAG. Rather, ageing is associated with changes in chylomicron particle size, apoB content and fatty acid composition of the chylomicron TAG and PL fractions. |
en |
dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/26767323 |
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dc.format.medium |
Print-Electronic |
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dc.language |
English |
en |
dc.publisher |
Cambridge University Press |
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dc.relation.ispartofseries |
British Journal of Nutrition |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from https://www.cambridge.org/core/services/open-access-policies |
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dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Humans |
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dc.subject |
Insulin |
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dc.subject |
Blood Glucose |
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dc.subject |
Dietary Fats |
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dc.subject |
Oleic Acid |
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dc.subject |
Triglycerides |
en |
dc.subject |
Chylomicrons |
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dc.subject |
Apolipoproteins B |
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dc.subject |
Cross-Sectional Studies |
en |
dc.subject |
Aging |
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dc.subject |
Postprandial Period |
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dc.subject |
Particle Size |
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dc.subject |
Adult |
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dc.subject |
Aged |
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dc.subject |
Middle Aged |
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dc.subject |
Female |
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dc.subject |
Male |
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dc.subject |
Hyperlipidemias |
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dc.subject |
Young Adult |
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dc.subject |
Diet, High-Fat |
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dc.subject |
Meals |
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dc.title |
Older adults have an altered chylomicron response to a high-fat meal |
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dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1017/S000711451500505X |
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pubs.issue |
5 |
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pubs.begin-page |
791 |
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pubs.volume |
115 |
en |
dc.description.version |
VoR - Version of Record |
en |
dc.identifier.pmid |
26767323 |
en |
pubs.author-url |
https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/div-classtitleolder-adults-have-an-altered-chylomicron-response-to-a-high-fat-mealdiv/578527C5312622BFFB78935240097E1C |
en |
pubs.end-page |
799 |
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pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
517715 |
en |
pubs.org-id |
Liggins Institute |
en |
dc.identifier.eissn |
1475-2662 |
en |
pubs.record-created-at-source-date |
2017-02-13 |
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pubs.dimensions-id |
26767323 |
en |