Non-Dipping and Cardiometabolic Profile: A study on normotensive overweight middle-aged men

Show simple item record Albert, Benjamin en de Bock, M en Behrensdorf Derraik, Jose en Brennan, CM en Biggs, Janene en Hofman, Paul en Cutfield, Wayne en 2017-02-17T03:13:07Z en 2016-12 en
dc.identifier.citation Heart, Lung and Circulation 25(12):1218-1225 Dec 2016 en
dc.identifier.issn 1443-9506 en
dc.identifier.uri en
dc.description.abstract We aimed to assess insulin sensitivity and other metabolic features of dippers and non-dippers among overweight middle-aged men.We studied 73 men (45.8 ± 5.3 years) who were overweight but normotensive. Participants were separated into dippers and non-dippers based on the magnitude of the nocturnal decline of blood pressure, with dippers experiencing an overnight decline ≥10% as per standard definition. Our study included 51 dippers and 22 non-dippers. All participants underwent 24-hour ambulatory blood pressure monitoring. Insulin sensitivity was assessed by the Matsuda method from an oral glucose tolerance test; other assessments included carotid artery intima-media thickness (CIMT), body composition derived from dual-energy X-ray absorptiometry, lipid profiles, and a physical activity questionnaire.Non-dippers had lower daytime systolic (-5.0mmHg; p=0.022) and diastolic (-3.3mmHg; p=0.035) blood pressure than dippers. Conversely, during sleep, non-dippers had higher systolic (+6.5mmHg; p=0.003) and diastolic (+5.6mmHg; p=0.001) blood pressure. In continuous associations, increasing CIMT was associated with decreasing systolic (p=0.012) and diastolic (p=0.042) dipping. Thus, non-dippers had CIMT that was 9% greater than that of dippers (749 vs 820μm; p=0.036). Importantly, there was no association between non-dipping status or the magnitude of the nocturnal dip with insulin sensitivity.Non-dippers had lower blood pressure in the daytime, but higher blood pressure in the night time compared to dippers. Non-dippers had increased CIMT, which suggests that normotensive men with a non-dipping ambulatory blood pressure profile may be at increased cardiovascular risk. However, it appears that the non-dipping profile is unrelated to dysfunction of glucose homeostasis in overweight normotensive men. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.publisher Blackwell Publishing Inc. en
dc.relation.ispartofseries Heart, Lung and Circulation en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Non-Dipping and Cardiometabolic Profile: A study on normotensive overweight middle-aged men en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.hlc.2016.04.012 en
pubs.issue 12 en
pubs.begin-page 1218 en
pubs.volume 25 en
dc.identifier.pmid 27324178 en
pubs.end-page 1225 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 531498 en Liggins Institute en Medical and Health Sciences en School of Medicine en Paediatrics Child & Youth Hlth en
dc.identifier.eissn 1444-2892 en
pubs.record-created-at-source-date 2017-02-17 en 2016-05-17 en
pubs.dimensions-id 27324178 en

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