dc.contributor.author |
Albert, Benjamin |
en |
dc.contributor.author |
de Bock, M |
en |
dc.contributor.author |
Behrensdorf Derraik, Jose |
en |
dc.contributor.author |
Brennan, CM |
en |
dc.contributor.author |
Biggs, Janene |
en |
dc.contributor.author |
Hofman, Paul |
en |
dc.contributor.author |
Cutfield, Wayne |
en |
dc.date.accessioned |
2017-02-17T03:13:07Z |
en |
dc.date.issued |
2016-12 |
en |
dc.identifier.citation |
Heart, Lung and Circulation 25(12):1218-1225 Dec 2016 |
en |
dc.identifier.issn |
1443-9506 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/31878 |
en |
dc.description.abstract |
We aimed to assess insulin sensitivity and other metabolic features of dippers and non-dippers among overweight middle-aged men.We studied 73 men (45.8 ± 5.3 years) who were overweight but normotensive. Participants were separated into dippers and non-dippers based on the magnitude of the nocturnal decline of blood pressure, with dippers experiencing an overnight decline ≥10% as per standard definition. Our study included 51 dippers and 22 non-dippers. All participants underwent 24-hour ambulatory blood pressure monitoring. Insulin sensitivity was assessed by the Matsuda method from an oral glucose tolerance test; other assessments included carotid artery intima-media thickness (CIMT), body composition derived from dual-energy X-ray absorptiometry, lipid profiles, and a physical activity questionnaire.Non-dippers had lower daytime systolic (-5.0mmHg; p=0.022) and diastolic (-3.3mmHg; p=0.035) blood pressure than dippers. Conversely, during sleep, non-dippers had higher systolic (+6.5mmHg; p=0.003) and diastolic (+5.6mmHg; p=0.001) blood pressure. In continuous associations, increasing CIMT was associated with decreasing systolic (p=0.012) and diastolic (p=0.042) dipping. Thus, non-dippers had CIMT that was 9% greater than that of dippers (749 vs 820μm; p=0.036). Importantly, there was no association between non-dipping status or the magnitude of the nocturnal dip with insulin sensitivity.Non-dippers had lower blood pressure in the daytime, but higher blood pressure in the night time compared to dippers. Non-dippers had increased CIMT, which suggests that normotensive men with a non-dipping ambulatory blood pressure profile may be at increased cardiovascular risk. However, it appears that the non-dipping profile is unrelated to dysfunction of glucose homeostasis in overweight normotensive men. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
Blackwell Publishing Inc. |
en |
dc.relation.ispartofseries |
Heart, Lung and Circulation |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Non-Dipping and Cardiometabolic Profile: A study on normotensive overweight middle-aged men |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.hlc.2016.04.012 |
en |
pubs.issue |
12 |
en |
pubs.begin-page |
1218 |
en |
pubs.volume |
25 |
en |
dc.identifier.pmid |
27324178 |
en |
pubs.end-page |
1225 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
531498 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Paediatrics Child & Youth Hlth |
en |
dc.identifier.eissn |
1444-2892 |
en |
pubs.record-created-at-source-date |
2017-02-17 |
en |
pubs.online-publication-date |
2016-05-17 |
en |
pubs.dimensions-id |
27324178 |
en |