dc.contributor.author |
Law, CJ |
en |
dc.contributor.author |
Jacobson, GM |
en |
dc.contributor.author |
Kluger, M |
en |
dc.contributor.author |
Chaddock, M |
en |
dc.contributor.author |
Scott, M |
en |
dc.contributor.author |
Sleigh, James |
en |
dc.coverage.spatial |
England |
en |
dc.date.accessioned |
2017-02-24T02:00:55Z |
en |
dc.date.available |
2013-08-22 |
en |
dc.date.issued |
2014-04 |
en |
dc.identifier.citation |
British Journal of Anaesthesia, April 2014, 112 (4), 675 - 680 |
en |
dc.identifier.issn |
0007-0912 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/31958 |
en |
dc.description.abstract |
BACKGROUND: Our hypothesis was that deep anaesthesia, as estimated by a low target bispectral index (BIS) of 30-40, would result in less postoperative pain than that achieved at a conventional depth of anaesthesia. METHODS: We undertook a randomized double-blind controlled study at two tertiary teaching hospitals in New Zealand (2010-1) recruiting 135 adult patients ASA I-II presenting for non-emergent surgery under general anaesthesia requiring tracheal intubation. Anaesthesia was maintained with desflurane and a multimodal analgesia regimen comprising fentanyl infusion, i.v. paracetamol, and parecoxib. Patients were randomly assigned to either a low BIS (30-40) group or a high BIS (45-60) group. Desflurane concentrations were titrated to achieve these targets. Postoperative pain was assessed by: the pain on awakening (0-10, verbal rating scale, VRS(awake)) in the post-anaesthetic care unit; pain on activity at 20-24 h after operation (VRS(d1A)); and the rate of morphine patient-controlled analgesia (PCA) usage over the first 24 h. RESULTS: There was no statistically significant difference between the two groups for any of the pain scores. The median [inter-quartile range (IQR)] VRS(awake) was 4.0 (0-8) for the low and 4.0 (0-8) for the high BIS groups (P=0.56). The median (IQR) VRS(d1A) was 3.0 (1-5) for the low and 3.0 (1.5-4.5) for the high BIS groups (P=0.83). The median PCA morphine consumption in the low BIS group was 0.61 mg h(-1) (0.04-1.5) vs 0.43 mg h(-1) (0-1.59) in the high BIS group (P=0.98). CONCLUSIONS: We conclude that there is no clinically useful analgesic effect of a deep anaesthesia regimen. |
en |
dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/24322572 |
en |
dc.language |
English |
en |
dc.publisher |
Oxford University Press |
en |
dc.relation.ispartofseries |
British Journal of Anaesthesia |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0007-0912/
https://academic.oup.com/journals/pages/access_purchase/rights_and_permissions/self_archiving_policy_b |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
depth of anaesthesia |
en |
dc.subject |
postoperative pain |
en |
dc.subject |
Adolescent |
en |
dc.subject |
Adult |
en |
dc.subject |
Aged |
en |
dc.subject |
Analgesia, Patient-Controlled |
en |
dc.subject |
Analgesics, Opioid |
en |
dc.subject |
Anesthesia, General |
en |
dc.subject |
Anesthetics, Inhalation |
en |
dc.subject |
Double-Blind Method |
en |
dc.subject |
Drug Administration Schedule |
en |
dc.subject |
Electroencephalography |
en |
dc.subject |
Female |
en |
dc.subject |
Fentanyl |
en |
dc.subject |
Humans |
en |
dc.subject |
Isoflurane |
en |
dc.subject |
Male |
en |
dc.subject |
Middle Aged |
en |
dc.subject |
Monitoring, Intraoperative |
en |
dc.subject |
Morphine |
en |
dc.subject |
Pain Measurement |
en |
dc.subject |
Pain, Postoperative |
en |
dc.subject |
Young Adult |
en |
dc.title |
Randomized controlled trial of the effect of depth of anaesthesia on postoperative pain |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1093/bja/aet419 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
675 |
en |
pubs.volume |
112 |
en |
dc.description.version |
VoR - Version of Record |
en |
dc.identifier.pmid |
24322572 |
en |
pubs.author-url |
https://academic.oup.com/bja/article-lookup/doi/10.1093/bja/aet419 |
en |
pubs.end-page |
680 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
420715 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Anaesthesiology |
en |
dc.identifier.eissn |
1471-6771 |
en |
dc.identifier.pii |
aet419 |
en |
pubs.record-created-at-source-date |
2017-02-24 |
en |
pubs.online-publication-date |
2013-12-08 |
en |
pubs.dimensions-id |
24322572 |
en |