dc.contributor.author |
Voss, LJ |
en |
dc.contributor.author |
Baas, CH |
en |
dc.contributor.author |
Hansson, L |
en |
dc.contributor.author |
Steyn-Ross, DA |
en |
dc.contributor.author |
Steyn-Ross, M |
en |
dc.contributor.author |
Sleigh, James |
en |
dc.coverage.spatial |
Netherlands |
en |
dc.date.accessioned |
2017-02-24T03:08:39Z |
en |
dc.date.available |
2012-06-07 |
en |
dc.date.issued |
2012-08-15 |
en |
dc.identifier.citation |
European Journal of Pharmacology, 15 August 2012, 689 (1-3), 111 - 117 |
en |
dc.identifier.issn |
0014-2999 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/31962 |
en |
dc.description.abstract |
General anaesthetics have been hypothesised to ablate consciousness by decoupling intracortical neural connectivity. We explored this by investigating the effect of etomidate and ketamine on coupling of neural population activity using the low magnesium neocortical slice model. Four extracellular electrodes (50 μm) were positioned in mouse neocortical slices (400 μm thick) with varying separation. The effect of etomidate (24 μM) and ketamine (16 μM) on the timing of population activity recorded between channels was analysed. No decoupling was observed at the closest electrode separation of 0.2 mm. At 4mm separation, decoupling was observed in 50% and 42% of slices during etomidate and ketamine delivery, respectively (P<0.0001 and P=0.002, compared to 0.2 mm separation). A lower rate of decoupling was observed with 1mm separation (21% and 8%, respectively, P<0.03 for etomidate compared to 0.2mm separation). The data support the hypothesis that mechanistically diverse general anaesthetics disrupt neuronal connectivity across widely distributed intracortical networks. |
en |
dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/22705895 |
en |
dc.language |
English |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
European Journal of Pharmacology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0014-2999/
https://www.elsevier.com/about/company-information/policies/sharing |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Action Potentials |
en |
dc.subject |
Anesthetics, General |
en |
dc.subject |
Animals |
en |
dc.subject |
Etomidate |
en |
dc.subject |
Female |
en |
dc.subject |
Ketamine |
en |
dc.subject |
Male |
en |
dc.subject |
Mice |
en |
dc.subject |
Mice, 129 Strain |
en |
dc.subject |
Mice, Inbred C57BL |
en |
dc.subject |
Neocortex |
en |
dc.subject |
Neurons |
en |
dc.subject |
Organ Culture Techniques |
en |
dc.title |
Investigation into the effect of the general anaesthetics etomidate and ketamine on long-range coupling of population activity in the mouse neocortical slice |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.ejphar.2012.06.003 |
en |
pubs.issue |
1-3 |
en |
pubs.begin-page |
111 |
en |
pubs.volume |
689 |
en |
dc.description.version |
VoR - Version of Record |
en |
dc.identifier.pmid |
22705895 |
en |
pubs.author-url |
http://www.sciencedirect.com/science/article/pii/S0014299912005146 |
en |
pubs.end-page |
117 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
357574 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Anaesthesiology |
en |
dc.identifier.eissn |
1879-0712 |
en |
dc.identifier.pii |
S0014-2999(12)00514-6 |
en |
pubs.record-created-at-source-date |
2017-02-24 |
en |
pubs.online-publication-date |
2012-06-15 |
en |
pubs.dimensions-id |
22705895 |
en |