dc.contributor.author |
Li, D |
en |
dc.contributor.author |
Li, X |
en |
dc.contributor.author |
Hagihira, S |
en |
dc.contributor.author |
Sleigh, James |
en |
dc.coverage.spatial |
England |
en |
dc.date.accessioned |
2017-02-24T04:10:24Z |
en |
dc.date.available |
2012-08-24 |
en |
dc.date.issued |
2013-03 |
en |
dc.identifier.citation |
British Journal of Anaesthesia, March 2013, 110 (3), 409 - 419 |
en |
dc.identifier.issn |
0007-0912 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/31968 |
en |
dc.description.abstract |
BACKGROUND: Fourier bicoherence has previously been applied to investigate phase coupling in the EEG in anaesthesia. However, there are significant theoretical limitations regarding its sensitivity in detecting transient episodes of inter-frequency coupling. Therefore, we used a recently developed wavelet bicoherence method to investigate the cross-frequency coupling in the EEG of patients under isoflurane anaesthesia; examining the relationship between the patterns of wavelet bicoherence and the isoflurane concentrations. METHODS: We analysed a set of previously published EEG data, obtained from 29 patients who underwent elective abdominal surgery under isoflurane anaesthesia. Artifact-free, 1 min EEG segments at different isoflurane concentrations were extracted from each subject and the wavelet bicoherence calculated for all pairs of frequencies from 0.5 to 20 Hz. RESULTS: Isoflurane caused two peaks in the α (6-13 Hz) and slow δ (<1 Hz) regions of the bicoherence matrix diagonal. Higher concentrations of isoflurane shifted the α peak to lower frequencies [11.3 (0.9) Hz at 0.3% to 7.1 (1.2) Hz at 1.5%], as has been previously observed in the power spectra. Outside the diagonal, we also found a significant α peak that was phase-coupled to the slow δ waves; higher concentrations of isoflurane shifted this peak to lower frequencies [10.8 (1.2) to 7.7 (0.7) Hz]. CONCLUSIONS: Isoflurane caused cross-frequency coupling between α and slow δ waves. Increasing isoflurane concentration slowed the α frequencies where the coupling had occurred. This phenomenon of α-δ coupling suggests that slow cortical oscillations organize the higher α band activity, which is consistent with other studies in natural sleep. |
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dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/23161358 |
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dc.language |
English |
en |
dc.publisher |
Oxford University Press |
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dc.relation.ispartofseries |
British Journal of Anaesthesia |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0007-0912/
https://academic.oup.com/journals/pages/access_purchase/rights_and_permissions/self_archiving_policy_b |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Adult |
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dc.subject |
Aged |
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dc.subject |
Alpha Rhythm |
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dc.subject |
Anesthesia, Inhalation |
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dc.subject |
Anesthetics, Inhalation |
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dc.subject |
Artifacts |
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dc.subject |
Data Interpretation, Statistical |
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dc.subject |
Dose-Response Relationship, Drug |
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dc.subject |
Electroencephalography |
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dc.subject |
Female |
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dc.subject |
Humans |
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dc.subject |
Isoflurane |
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dc.subject |
Male |
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dc.subject |
Middle Aged |
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dc.subject |
Monitoring, Intraoperative |
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dc.subject |
Sample Size |
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dc.subject |
Signal Processing, Computer-Assisted |
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dc.subject |
Wavelet Analysis |
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dc.title |
Cross-frequency coupling during isoflurane anaesthesia as revealed by electroencephalographic harmonic wavelet bicoherence |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1093/bja/aes397 |
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pubs.issue |
3 |
en |
pubs.begin-page |
409 |
en |
pubs.volume |
110 |
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dc.description.version |
VoR - Version of Record |
en |
dc.identifier.pmid |
23161358 |
en |
pubs.author-url |
https://academic.oup.com/bja/article-lookup/doi/10.1093/bja/aes397 |
en |
pubs.end-page |
419 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
364364 |
en |
pubs.org-id |
Medical and Health Sciences |
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pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Anaesthesiology |
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dc.identifier.eissn |
1471-6771 |
en |
dc.identifier.pii |
aes397 |
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pubs.record-created-at-source-date |
2017-02-24 |
en |
pubs.online-publication-date |
2012-11-15 |
en |
pubs.dimensions-id |
23161358 |
en |