Acute aerobic exercise modulates primary motor cortex inhibition

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dc.contributor.author Mooney, Ronan en
dc.contributor.author Coxon, JP en
dc.contributor.author Cirillo, John en
dc.contributor.author Glenny, H en
dc.contributor.author Gant, N en
dc.contributor.author Byblow, Winston en
dc.date.accessioned 2017-03-02T23:24:28Z en
dc.date.issued 2016-12 en
dc.identifier.citation Experimental Brain Research 234(12):3669-3676 Dec 2016 en
dc.identifier.issn 0014-4819 en
dc.identifier.uri http://hdl.handle.net/2292/32035 en
dc.description.abstract Aerobic exercise can enhance neuroplasticity although presently the neural mechanisms underpinning these benefits remain unclear. One possible mechanism is through effects on primary motor cortex (M1) function via down-regulation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). The aim of the present study was to examine how corticomotor excitability (CME) and M1 intracortical inhibition are modulated in response to a single bout of moderate intensity aerobic exercise. Ten healthy right-handed adults were participants. Single- and paired-pulse transcranial magnetic stimulation was applied over left M1 to obtain motor-evoked potentials in the right flexor pollicis brevis. We examined CME, cortical silent period (SP) duration, short- and long-interval intracortical inhibition (SICI, LICI), and late cortical disinhibition (LCD), before and after acute aerobic exercise (exercise session) or an equivalent duration without exercise (control session). Aerobic exercise was performed on a cycle ergometer for 30 min at a workload equivalent to 60 % of maximal cardiorespiratory fitness (VO2 peak; heart rate reserve = 75 ± 3 %, perceived exertion = 13.5 ± 0.7). LICI was reduced at 10 (52 ± 17 %, P = 0.03) and 20 min (27 ± 8 %, P = 0.03) post-exercise compared to baseline (13 ± 4 %). No significant changes in CME, SP duration, SICI or LCD were observed. The present study shows that GABAB-mediated intracortical inhibition may be down-regulated after acute aerobic exercise. The potential effects this may have on M1 plasticity remain to be determined. en
dc.publisher Springer Verlag en
dc.relation.ispartofseries Experimental Brain Research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0014-4819/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Acute aerobic exercise modulates primary motor cortex inhibition en
dc.type Journal Article en
dc.identifier.doi 10.1007/s00221-016-4767-5 en
pubs.issue 12 en
pubs.begin-page 3669 en
pubs.volume 234 en
dc.description.version AM - Accepted Manuscript en
dc.rights.holder Copyright: Springer Verlag en
dc.identifier.pmid 27590480 en
pubs.end-page 3676 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 541189 en
pubs.org-id Science en
pubs.org-id Exercise Sciences en
dc.identifier.eissn 1432-1106 en
pubs.record-created-at-source-date 2017-03-03 en
pubs.online-publication-date 2016-09-02 en
pubs.dimensions-id 27590480 en


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