Urate-lowering therapy for asymptomatic hyperuricaemia: A need for caution

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dc.contributor.author Stamp, L en
dc.contributor.author Dalbeth, Nicola en
dc.date.accessioned 2017-03-03T00:38:11Z en
dc.date.issued 2017-02 en
dc.identifier.citation Seminars in Arthritis and Rheumatism 46(4):457-464 Feb 2017 en
dc.identifier.issn 0049-0172 en
dc.identifier.uri http://hdl.handle.net/2292/32039 en
dc.description.abstract Objective The observed associations of hyperuricaemia with hypertension, cardiovascular disease and kidney disease are receiving increasing interest. The potential role of urate-lowering therapy in the management of these “non-gout diseases” has been raised, and in some countries it is already recommended. However, there is no consistent definition of hyperuricaemia or asymptomatic hyperuricaemia, much remains unknown about the causal role of urate in these “non-gout diseases” and there is currently a lack of evidence about the effects of urate lowering on disease progression. In addition, there is potential for serious adverse effects associated with urate-lowering therapies with recent evidence suggesting that asymptomatic hyperuricaemia may be an independent risk factor for the potentially fatal allopurinol hypersensitivity syndrome. Methods Pubmed was searched in January 2016 using the search term “asymptomatic hyperuricaemia”. Results and Conclusions Herein, we discuss the issues related to treating asymptomatic hyperuricaemia, which at present seems premature. en
dc.publisher Elsevier en
dc.relation.ispartofseries Seminars in Arthritis and Rheumatism en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Urate-lowering therapy for asymptomatic hyperuricaemia: A need for caution en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.semarthrit.2016.07.015 en
pubs.issue 4 en
pubs.begin-page 457 en
pubs.volume 46 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 27591828 en
pubs.end-page 464 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 541262 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
dc.identifier.eissn 1532-866X en
pubs.record-created-at-source-date 2017-03-03 en
pubs.online-publication-date 2016-07 en
pubs.dimensions-id 27591828 en

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