Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice

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dc.contributor.author Aitken, Jacqueline en
dc.contributor.author Loomes, Kerry en
dc.contributor.author Riba-Garcia, I en
dc.contributor.author Unwin, RD en
dc.contributor.author Prijic, G en
dc.contributor.author Phillips, AS en
dc.contributor.author Phillips, Anthony en
dc.contributor.author Wu, D en
dc.contributor.author Poppitt, Sally en
dc.contributor.author Ding, K en
dc.contributor.author Barran, PE en
dc.contributor.author Dowsey, AW en
dc.contributor.author Cooper, Garth en
dc.date.accessioned 2017-03-03T04:29:25Z en
dc.date.available 2016-11-23 en
dc.date.issued 2017-02 en
dc.identifier.citation Data in Brief, February 2017, 10, 298 - 303 en
dc.identifier.issn 2352-3409 en
dc.identifier.uri http://hdl.handle.net/2292/32045 en
dc.description.abstract Here we provide data describing the time-course of blood-glucose and fluid-intake profiles of diabetic hemizygous human-amylin (hA) transgenic mice orally treated with rutin, and matched control mice treated with water. We employed “parametric change-point regression analysis” for investigation of differences in time-course profiles between the control and rutin-treatment groups to extract, for each animal, baseline levels of blood glucose and fluid-intake, the change-point time at which blood glucose (diabetes-onset) and fluid-intake (polydipsia-onset) accelerated away from baseline, and the rate of this acceleration. The parametric change-point regression approach applied here allowed a much more accurate determination of the exact time of onset of diabetes than do the standard diagnostic criteria. These data are related to the article entitled “Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice” (J.F. Aitken, K.M. Loomes, I. Riba-Garcia, R.D. Unwin, G. Prijic, A.S. Phillips, A.R.J. Phillips, D. Wu, S.D. Poppitt, K. Ding, P.E. Barran, A.W. Dowsey, G.J.S. Cooper. 2016) [1]. en
dc.description.uri https://www.ncbi.nlm.nih.gov/pubmed/27995166 en
dc.language English en
dc.publisher Elsevier en
dc.relation.ispartofseries Data in Brief en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/2352-3409/ https://www.elsevier.com/about/open-science/open-access en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.title Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.dib.2016.11.077 en
pubs.begin-page 298 en
pubs.volume 10 en
dc.description.version VoR - Version of Record en
dc.identifier.pmid 27995166 en
pubs.author-url http://www.sciencedirect.com/science/article/pii/S2352340916307375 en
pubs.end-page 303 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 603738 en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 2352-3409 en
pubs.record-created-at-source-date 2017-03-03 en
pubs.online-publication-date 2016-11-29 en
pubs.dimensions-id 27995166 en

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